(2R)-2-Phenylpropanoic acid(CAS: 7782-26-5)

(2R)-2-Phenylpropanoic acid is a white crystalline solid with a molecular weight of approximately 146.21 g/mol. It has a pKa of about 3.5 and is slightly soluble in water but more soluble in organic solvents. It is reactive towards basic conditions and can undergo various esterification and amidation reactions.

(2R)-2-Phenylpropanoic acid can be synthesized via a Grignard reaction of phenylmagnesium bromide with propanoyl chloride, followed by hydrolysis to yield the carboxylic acid. This method provides good yield and selectivity, and appropriate catalysts can enhance the reaction efficiency.

(2R)-2-Phenylpropanoic acid is used in the pharmaceutical industry as a precursor for several drug molecules, in polymer synthesis for functional polymers, and in the production of organic sensors and semiconductors due to its unique chemical properties and functionality.

When handling (2R)-2-Phenylpropanoic acid, wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat. Store in a cool, dry place away from direct sunlight and heat sources. Use a fume hood during operations to avoid inhalation. In case of spill, immediately clean up using appropriate absorbents and consult the Safety Data Sheet (SDS) for further instructions.