Ethyl 2-piperidinecarboxylate hydrochloride (1:1)

Basic Information

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CAS Number

77034-33-4

Molecular Formula

C8H16ClNO2

Molecular Weight

193.67 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

211-213 °C

SMILES

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CCOC(=O)C1CCCCN1.Cl

InChI

InChI=1S/C8H15NO2.ClH/c1-2-11-8(10)7-5-3-4-6-9-7;/h7,9H,2-6H2,1H3;1H

InChIKey

KGAWPIXNSIYQPC-UHFFFAOYSA-N

LogP

1.1134

Topological Polar Surface Area

38.33 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

136

Safety Information

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GHS Hazard Pictograms

H318

Hazard Statement

H318 Causes serious eye damage
Serious eye damage/eye irritation

Synonyms & References

English

Ethyl pipecolinate hydrochloride
SB43070
FT-0641631
Ethyl Piperidine-2-carboxylate hydrochloride
DTXSID00498201
SB42965
CDA03433
CS-0042722
SB45089
Ethylpiperidine-2-carboxylatehydrochloride
SY107101
Z104474224
MFCD00134518
SCHEMBL1282288
A838946
Ethyl piperidine-2-carboxylate--hydrogen chloride (1/1)
ETHYL PIPERIDINE-2-CARBOXYLATE HCL
AKOS015897854
EN300-19559
AM20100763
Ethyl 2-piperidinecarboxylate hydrochloride
77034-33-4
ethyl piperidine-2-carboxylate;hydrochloride
ethyl 1-piperidine-2-carboxylate hydrochloride
MFCD09264372
2-piperidinecarboxylic acid ethyl ester hydrochloride
Ethyl pipecolinate hydrochloride, 97%
Ethyl pipecolinate HCl
SY023683
KGAWPIXNSIYQPC-UHFFFAOYSA-N
Piperidine-2-carboxylic acid ethyl ester hydrochloride

MDL Number

MFCD00134518

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Ethyl 2-piperidinecarboxylate hydrochloride (CAS: 77034-33-4)?

Ethyl 2-piperidinecarboxylate hydrochloride (CAS: 77034-33-4) is a crystalline solid with a molecular weight of approximately 195.7 g/mol. It has a pKa of around 1.6 and is soluble in water and ethanol. This compound is known for its reactivity towards nucleophiles and its ability to form salts with various cations. It is commonly used in organic synthesis and as a precursor in the pharmaceutical and polymer industries.

How is Ethyl 2-piperidinecarboxylate hydrochloride (CAS: 77034-33-4) typically synthesized?

Ethyl 2-piperidinecarboxylate hydrochloride (CAS: 77034-33-4) can be synthesized by reacting piperidine with ethyl chloroacetate in the presence of a catalytic amount of a base like sodium bicarbonate. The reaction is typically carried out in an organic solvent such as methanol or ethanol, yielding the desired hydrochloride salt in high yield and good selectivity.

What industries use Ethyl 2-piperidinecarboxylate hydrochloride (CAS: 77034-33-4)?

Ethyl 2-piperidinecarboxylate hydrochloride (CAS: 77034-33-4) is used in the pharmaceutical industry for the synthesis of certain drugs, in polymer production to enhance material properties, and in the development of sensors and semiconductors due to its chemical reactivity and ability to form stable derivatives.

What precautions should be taken when handling Ethyl 2-piperidinecarboxylate hydrochloride (CAS: 77034-33-4)?

When handling Ethyl 2-piperidinecarboxylate hydrochloride (CAS: 77034-33-4), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. It should be stored in a cool, dry place away from direct sunlight and heat sources. In case of spills, they should be cleaned up immediately using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed information on safe handling and emergency procedures.