Compound Q&A

How is Ethyl 2-piperidinecarboxylate hydrochloride (CAS: 77034-33-4) typically synthesized?

Answer

Ethyl 2-piperidinecarboxylate hydrochloride (1:1)
Ethyl 2-piperidinecarboxylate hydrochloride (CAS: 77034-33-4) can be synthesized by reacting piperidine with ethyl chloroacetate in the presence of a catalytic amount of a base like sodium bicarbonate. The reaction is typically carried out in an organic solvent such as methanol or ethanol, yielding the desired hydrochloride salt in high yield and good selectivity.

About

CAS No 77034-33-4
English Name Ethyl 2-piperidinecarboxylate hydrochloride (1:1)
Molecular Formula C8H16ClNO2
Molecular Weight 193.67399999999995 g/mol
SMILES CCOC(=O)C1CCCCN1.Cl
InChIKey KGAWPIXNSIYQPC-UHFFFAOYSA-N
Last Updated: 2025-10-01 13:51

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