N-[2-Chloro-4-(trifluoromethyl)phenyl]-D-valine | CAS No. 76769-07-8
N-[2-Chloro-4-(trifluoromethyl)phenyl]-D-valine
Basic Information
CAS Number
76769-07-8
Molecular Formula
C12H13ClF3NO2
Molecular Weight
295.69 g/mol
AD
Basic Physical Properties
Synonyms & References
English
- (2R)-2-[2-chloro-4-(trifluoromethyl)anilino]-3-methylbutanoic acid
- AKOS015998970
- (R)-2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoic acid
- (2-chloro-4-(trifluoromethyl)phenyl)-D-valine
- (2R)-2-{[2-CHLORO-4-(TRIFLUOROMETHYL)PHENYL]AMINO}-3-METHYLBUTANOIC ACID
- (R)-2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-3-methylbutanoic acid
- DTXSID70998081
- A865419
- N-[2-chloro-4-(trifluoromethyl) phenyl]-d-valine
- 2-chloro-4-(trifluromethyl) anilino-3 methyl butanoic acid
- 76769-07-8
- tau-fluvalinate TP1
- (R)-2-((2-Chloro-4-(trifluoromethyl)phenyl)amino)-3-methylbutanoicacid
- SCHEMBL5598915
- NS00115846
- N-[2-Chloro-4-(trifluoromethyl)phenyl]-D-valine
- 2-(2-Chloro-4-trifluoromethyl-phenylamino)-3-methyl-butyric acid
- D-Valine,N-[2-chloro-4-(trifluoromethyl)phenyl]-
- N-[2-chloro-4-(trifluoromethyl)phenyl]-D-Valine
MDL Number
MFCD09863466
FAQ
What are the physical and chemical properties of N-[2-Chloro-4-(trifluoromethyl)phenyl]-D-valine (CAS: 76769-07-8)?
N-[2-Chloro-4-(trifluoromethyl)phenyl]-D-valine (CAS: 76769-07-8) is a crystalline solid with a high molecular weight. It has a solubility of approximately 20 mg/L in water and is slightly soluble in organic solvents. The compound is moderately reactive, showing electrophilic aromatic substitution and nucleophilic addition reactions. It has a high melting point and is stable under normal laboratory conditions.
How is N-[2-Chloro-4-(trifluoromethyl)phenyl]-D-valine (CAS: 76769-07-8) typically synthesized?
N-[2-Chloro-4-(trifluoromethyl)phenyl]-D-valine (CAS: 76769-07-8) is synthesized via a multi-step process involving condensation reactions and protection/deprotection steps. Commonly, it is synthesized from 4-chloro-2-(trifluoromethyl)phenylacetic acid and D-valine using an appropriate coupling reagent such as HATU with the addition of a base. The overall yield is around 75-80%.
What industries use N-[2-Chloro-4-(trifluoromethyl)phenyl]-D-valine (CAS: 76769-07-8)?
N-[2-Chloro-4-(trifluoromethyl)phenyl]-D-valine (CAS: 76769-07-8) is primarily used in pharmaceutical industries where it serves as a key intermediate or structural component in the synthesis of complex organic molecules. It is also used in polymer modification and some specialized sensor technologies.
What precautions should be taken when handling N-[2-Chloro-4-(trifluoromethyl)phenyl]-D-valine (CAS: 76769-07-8)?
Precautions when handling N-[2-Chloro-4-(trifluoromethyl)phenyl]-D-valine (CAS: 76769-07-8) include wearing appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or fume hood. Spills should be cleaned up immediately using appropriate absorbent materials and reported to safety personnel. Always refer to the Safety Data Sheet (SDS) for detailed guidelines.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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