N-[2-Chloro-4-(trifluoromethyl)phenyl]-D-valine(CAS: 76769-07-8)

N-[2-Chloro-4-(trifluoromethyl)phenyl]-D-valine (CAS: 76769-07-8) is a crystalline solid with a high molecular weight. It has a solubility of approximately 20 mg/L in water and is slightly soluble in organic solvents. The compound is moderately reactive, showing electrophilic aromatic substitution and nucleophilic addition reactions. It has a high melting point and is stable under normal laboratory conditions.

N-[2-Chloro-4-(trifluoromethyl)phenyl]-D-valine (CAS: 76769-07-8) is synthesized via a multi-step process involving condensation reactions and protection/deprotection steps. Commonly, it is synthesized from 4-chloro-2-(trifluoromethyl)phenylacetic acid and D-valine using an appropriate coupling reagent such as HATU with the addition of a base. The overall yield is around 75-80%.

N-[2-Chloro-4-(trifluoromethyl)phenyl]-D-valine (CAS: 76769-07-8) is primarily used in pharmaceutical industries where it serves as a key intermediate or structural component in the synthesis of complex organic molecules. It is also used in polymer modification and some specialized sensor technologies.

Precautions when handling N-[2-Chloro-4-(trifluoromethyl)phenyl]-D-valine (CAS: 76769-07-8) include wearing appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or fume hood. Spills should be cleaned up immediately using appropriate absorbent materials and reported to safety personnel. Always refer to the Safety Data Sheet (SDS) for detailed guidelines.