2-Ethoxy-3-iodopyridine

Basic Information

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CAS Number

766557-60-2

Molecular Formula

C7H8INO

Molecular Weight

249.05 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

255.3 °C at 760 mmHg

Density

1.714

Flash Point

108.2 °C

SMILES

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CCOC1=C(C=CC=N1)I

InChI

InChI=1S/C7H8INO/c1-2-10-7-6(8)4-3-5-9-7/h3-5H,2H2,1H3

InChIKey

QOCXFQFGXYWCHJ-UHFFFAOYSA-N

LogP

2.0849

Topological Polar Surface Area

22.12 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

99.6

Safety Information

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Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

AC-33270
2-ethoxy-3-iodopyridine
DTXSID90590329
SY271488
766557-60-2
DS-11411
FT-0652324
C76455
SCHEMBL1480240
2-Ethoxy-3-iodo-pyridine, AldrichCPR
AB05213
MFCD00234318
AKOS015838999
CS-W012662
A838786
AMY8046
2-Ethoxy-3-iodo-pyridine
2-Ethoxy-3-iodopyridine
2-ETHOXY-3-IODO-PYRIDINE
Pyridine,2-ethoxy-3-iodo
PubChem9248
Pyridine,2-ethoxy-3-iodo-
2-ethoxy-3-iodanyl-pyridine
9446AE
VP10743
TRA0010725
FCH1323336
OR345138
AK307638
AX8029588

MDL Number

MFCD00234318

FAQ

What are the physical and chemical properties of 2-Ethoxy-3-iodopyridine (CAS: 766557-60-2)?

2-Ethoxy-3-iodopyridine is a yellow crystalline solid with a molecular weight of approximately 265.14 g/mol. It is poorly soluble in water but soluble in organic solvents such as ethanol and acetone. Chemically, it is reactive towards nucleophiles and can undergo electrophilic aromatic substitution reactions.

How is 2-Ethoxy-3-iodopyridine (CAS: 766557-60-2) typically synthesized?

2-Ethoxy-3-iodopyridine can be synthesized via a multistep process involving the formation of an ethoxy derivative followed by iodination of the pyridine ring. Commonly, this involves the reaction of 3-chloropyridine with ethoxy magnesium bromide, followed by treatment with iodine in the presence of a base such as potassium carbonate.

What industries use 2-Ethoxy-3-iodopyridine (CAS: 766557-60-2)?

2-Ethoxy-3-iodopyridine is primarily used in the pharmaceutical industry for the development of novel drug candidates. It also finds applications in research for its reactivity in various chemical transformations and as a building block in the synthesis of other compounds.

What precautions should be taken when handling 2-Ethoxy-3-iodopyridine (CAS: 766557-60-2)?

Handling 2-Ethoxy-3-iodopyridine requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be thoroughly rinsed with water. Refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.