2-Ethoxy-3-iodopyridine(CAS: 766557-60-2)

2-Ethoxy-3-iodopyridine is a yellow crystalline solid with a molecular weight of approximately 265.14 g/mol. It is poorly soluble in water but soluble in organic solvents such as ethanol and acetone. Chemically, it is reactive towards nucleophiles and can undergo electrophilic aromatic substitution reactions.

2-Ethoxy-3-iodopyridine can be synthesized via a multistep process involving the formation of an ethoxy derivative followed by iodination of the pyridine ring. Commonly, this involves the reaction of 3-chloropyridine with ethoxy magnesium bromide, followed by treatment with iodine in the presence of a base such as potassium carbonate.

2-Ethoxy-3-iodopyridine is primarily used in the pharmaceutical industry for the development of novel drug candidates. It also finds applications in research for its reactivity in various chemical transformations and as a building block in the synthesis of other compounds.

Handling 2-Ethoxy-3-iodopyridine requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be thoroughly rinsed with water. Refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.