2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride (1:1)

Basic Information

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CAS Number

766545-20-4

Molecular Formula

C8H10Cl2N2

Molecular Weight

205.09 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

SMILES

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C1CNCC2=C1N=C(C=C2)Cl.Cl

InChI

InChI=1S/C8H9ClN2.ClH/c9-8-2-1-6-5-10-4-3-7(6)11-8;/h1-2,10H,3-5H2;1H

InChIKey

FRACHJCOMOVESL-UHFFFAOYSA-N

LogP

1.8024999999999998

Topological Polar Surface Area

24.92 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

140

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine HCl
2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine--hydrogen chloride (1/1)
2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine;hydrochloride
2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINEHYDROCHLORIDE
BCP21517
W-206592
2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE
SC2831
1,6-Naphthyridine, 2-chloro-5,6,7,8-tetrahydro
AKOS015846038
CS-D0309
FT-0648708
FRACHJCOMOVESL-UHFFFAOYSA-N
2-chloro-5,6,7,8-tetrahydro-[1,6]naphthyridine hydrochloride
MFCD09835503
1,6-Naphthyridine, 2-chloro-5,6,7,8-tetrahydro-, monohydrochloride
AMY14390
J-508805
2-Chloro-5 pound not6 pound not7 pound not8-tetrahydro-1 pound not6-naphthyridine hydrochloride
766545-20-4
2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride (1:1)
SCHEMBL1017773
SY006960
2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine, HCl
EN300-6487620
BCP19287
DTXSID20593904
2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride
PubChem14855
RP26136
RP04512

MDL Number

MFCD09835503

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride (CAS: 766545-20-4)?

2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride is a white crystalline solid with a molecular weight of approximately 277.66 g/mol. It is slightly soluble in water and alcohol. This compound shows moderate reactivity, particularly towards nucleophiles and bases. It has a pKa of around 2.5, indicating its acidic nature due to the presence of the hydrochloride group.

How is 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride (CAS: 766545-20-4) typically synthesized?

2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride can be synthesized via the condensation of 2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine with hydrochloric acid. The reaction is typically performed in a solvent such as ethanol or methanol. The yield is around 75-85%, and the purity can be enhanced through recrystallization from aqueous solutions.

What industries use 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride (CAS: 766545-20-4)?

2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the sensor industry for detection of specific chemical species. Additionally, it is utilized in research for its unique chemical properties and in the development of new materials.

What precautions should be taken when handling 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride (CAS: 766545-20-4)?

When handling 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Proper ventilation is necessary, and the use of a fume hood is recommended. Spills should be cleaned up promptly with appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed instructions on handling and disposal.