2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride (1:1)(CAS: 766545-20-4)

2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride is a white crystalline solid with a molecular weight of approximately 277.66 g/mol. It is slightly soluble in water and alcohol. This compound shows moderate reactivity, particularly towards nucleophiles and bases. It has a pKa of around 2.5, indicating its acidic nature due to the presence of the hydrochloride group.

2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride can be synthesized via the condensation of 2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine with hydrochloric acid. The reaction is typically performed in a solvent such as ethanol or methanol. The yield is around 75-85%, and the purity can be enhanced through recrystallization from aqueous solutions.

2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the sensor industry for detection of specific chemical species. Additionally, it is utilized in research for its unique chemical properties and in the development of new materials.

When handling 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Proper ventilation is necessary, and the use of a fume hood is recommended. Spills should be cleaned up promptly with appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed instructions on handling and disposal.