1-(3-Aminopropyl)-2-pyrrolidinone

Basic Information

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CAS Number

7663-77-6

Molecular Formula

C7H14N2O

Molecular Weight

142.2 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

120-123 °C/1 mmHg

Density

1.014 g/mL at 25 °C

Refractive Index

n20/D 1.5(lit.)

SMILES

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C1CC(=O)N(C1)CCCN

InChI

InChI=1S/C7H14N2O/c8-4-2-6-9-5-1-3-7(9)10/h1-6,8H2

InChIKey

HJORCZCMNWLHMB-UHFFFAOYSA-N

LogP

-0.04239999999999999

Topological Polar Surface Area

46.33 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

125

Safety Information

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GHS Hazard Pictograms

H314

Hazard Statement

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Synonyms & References

English

Z104473856
J-800145
1-(3-aminopropyl)pyrrolidin-2-one
SCHEMBL56994
1-(3-Aminopropyl)-2-pyrrolidinone
N-(3-Aminopropyl)pyrrolidin-2-one
NSC 108683
1-(3-amino-propyl)-pyrrolidin-2-one
MFCD00003201
BRN 0114960
N-(3'-AMINOPROPYL)-2-PYRROLIDINONE
1-(3-Aminopropyl)-2-pyrrolidinone #
1-(3-aminopropyl)pyrrolidinone
J-640141
Isoputreamine lactam
1-(3- aminopropyl)pyrrolidin-2-one
1-(3-aminopropyl)pyrrolidone
2-Pyrrolidinone, 1-(3-aminopropyl)-
N-(3-Aminopropyl)-2-pyrrolidinone
FT-0629164
NSC-108683
DTXSID80227455
1-(3-Aminopropyl)-2-pyrrolidone
n-3-aminopropyl-2-pyrrolidinone
7663-77-6
NSC108683
N-(3-Aminopropyl)-2-pyrrolidinone, technical grade
4-21-00-03163 (Beilstein Handbook Reference)
3-(2-oxo-1-pyrrolidinyl)-propylamine
EN300-19440
1-(3-aminopropyl)-pyrrolidin-2-one

MDL Number

MFCD00003201

Customs Code

2933790090

FAQ

What are the physical and chemical properties of 1-(3-Aminopropyl)-2-pyrrolidinone (CAS: 7663-77-6)?

1-(3-Aminopropyl)-2-pyrrolidinone (CAS: 7663-77-6) is a colorless to pale yellow liquid with a molecular weight of approximately 146.24 g/mol. It has a pKa of around 9.5. The compound is slightly soluble in water and miscible with ethanol and ether. It is chemically stable but can undergo hydrolysis in the presence of strong acids or bases. It is also known for its ability to form coordination complexes with metal ions.

How is 1-(3-Aminopropyl)-2-pyrrolidinone (CAS: 7663-77-6) typically synthesized?

1-(3-Aminopropyl)-2-pyrrolidinone is typically synthesized by reacting 3-aminopropylamine with pyrrolidone in the presence of an appropriate catalyst such as a Lewis acid. The reaction is exothermic and requires careful monitoring. The yield is usually around 90%, and the product can be purified by distillation or recrystallization.

What industries use 1-(3-Aminopropyl)-2-pyrrolidinone (CAS: 7663-77-6)?

1-(3-Aminopropyl)-2-pyrrolidinone (CAS: 7663-77-6) is used in various industrial applications including pharmaceuticals, where it serves as a solubilizing agent for poorly water-soluble drugs; in polymers, where it acts as a plasticizer; in sensors, as a reagent for detecting metal ions; and in semiconductor manufacturing, as a surfactant in cleaning processes.

What precautions should be taken when handling 1-(3-Aminopropyl)-2-pyrrolidinone (CAS: 7663-77-6)?

When handling 1-(3-Aminopropyl)-2-pyrrolidinone (CAS: 7663-77-6), it is important to wear appropriate personal protective equipment (PPE) including gloves and safety goggles. Work should be carried out in a well-ventilated area or a fume hood. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.