4-Fluoro-2-methylpyridine

Basic Information

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CAS Number

766-16-5

Molecular Formula

C6H6FN

Molecular Weight

111.12 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

128-132℃

Water Solubility

Slightly soluble in water.

Refractive Index

1.4715

SMILES

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CC1=NC=CC(=C1)F

InChI

InChI=1S/C6H6FN/c1-5-4-6(7)2-3-8-5/h2-4H,1H3

InChIKey

LEJYGRVERQVBLB-UHFFFAOYSA-N

LogP

1.5291199999999998

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

74.9

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

Air Sensitive

Synonyms & References

English

GS-6616
CS-W005007
FT-0646531
766-16-5
A838769
4-fluoro-2-methylpyridine
DTXSID10376480
AM62455
AB17919
4-Fluoro-2-picoline
MFCD04114145
SCHEMBL12443
AKOS005063649
4-fluoranyl-2-methyl-pyridine
2-Methyl-4-Fluoropyridine
trans-4-(Carbobenzoxyamino)cyclohexanecarboxylicAcid
LEJYGRVERQVBLB-UHFFFAOYSA-N
J-515665
A9709
SY021351
EN300-103099
4-Fluoro-2-methylpyridine
4-(MALEINIMIDO)PHENYL ISOCYANATE
4-fluoro-2-methyl-pyridine
PubChem21038
Pyridine,4-fluoro-2-methyl-
AB0009676
ST2411415
766F165

MDL Number

MFCD04114145

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 4-Fluoro-2-methylpyridine (CAS: 766-16-5)?

4-Fluoro-2-methylpyridine (CAS: 766-16-5) is a crystalline solid with a molecular weight of approximately 134.07 g/mol. It has a solubility of 1.7 g/L in water at 25°C. It exhibits low reactivity under normal conditions but can undergo electrophilic aromatic substitution reactions. Its melting point is around 73°C and boiling point is approximately 177°C.

How is 4-Fluoro-2-methylpyridine (CAS: 766-16-5) typically synthesized?

4-Fluoro-2-methylpyridine (CAS: 766-16-5) is commonly synthesized via electrophilic aromatic substitution of 2-methylpyridine with fluorine. The reaction typically involves treatment of 2-methylpyridine with a fluorinating agent such as DBF (dibenzylfluoride) or F2 in the presence of a Lewis acid catalyst like AlCl3 or BF3. The yield can be up to 80% under optimized conditions.

What industries use 4-Fluoro-2-methylpyridine (CAS: 766-16-5)?

4-Fluoro-2-methylpyridine (CAS: 766-16-5) finds applications in various industries, including pharmaceuticals, where it serves as a precursor for drug synthesis. It is also used in the polymer industry for the production of functionalized polymers and in the electronics industry for semiconductor applications. Additionally, it is utilized in sensor technology for detection purposes.

What precautions should be taken when handling 4-Fluoro-2-methylpyridine (CAS: 766-16-5)?

When handling 4-Fluoro-2-methylpyridine (CAS: 766-16-5), it is important to use appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up carefully using appropriate absorbents. Always consult the Safety Data Sheet (SDS) for detailed instructions on safe handling and emergency procedures.