4-Fluoro-2-methylpyridine(CAS: 766-16-5)

4-Fluoro-2-methylpyridine (CAS: 766-16-5) is a crystalline solid with a molecular weight of approximately 134.07 g/mol. It has a solubility of 1.7 g/L in water at 25°C. It exhibits low reactivity under normal conditions but can undergo electrophilic aromatic substitution reactions. Its melting point is around 73°C and boiling point is approximately 177°C.

4-Fluoro-2-methylpyridine (CAS: 766-16-5) is commonly synthesized via electrophilic aromatic substitution of 2-methylpyridine with fluorine. The reaction typically involves treatment of 2-methylpyridine with a fluorinating agent such as DBF (dibenzylfluoride) or F2 in the presence of a Lewis acid catalyst like AlCl3 or BF3. The yield can be up to 80% under optimized conditions.

4-Fluoro-2-methylpyridine (CAS: 766-16-5) finds applications in various industries, including pharmaceuticals, where it serves as a precursor for drug synthesis. It is also used in the polymer industry for the production of functionalized polymers and in the electronics industry for semiconductor applications. Additionally, it is utilized in sensor technology for detection purposes.

When handling 4-Fluoro-2-methylpyridine (CAS: 766-16-5), it is important to use appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up carefully using appropriate absorbents. Always consult the Safety Data Sheet (SDS) for detailed instructions on safe handling and emergency procedures.