3-benzyloxy-5-bromo-pyridin-2-amine

Basic Information

View in Editor

CAS Number

754230-78-9

Molecular Formula

C12H11BrN2O

Molecular Weight

279.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

99 ºC

Density

1.502

SMILES

View in Editor

C1=CC=C(C=C1)COC2=C(N=CC(=C2)Br)N

InChI

InChI=1S/C12H11BrN2O/c13-10-6-11(12(14)15-7-10)16-8-9-4-2-1-3-5-9/h1-7H,8H2,(H2,14,15)

InChIKey

ZFNMAJBVWOHSSF-UHFFFAOYSA-N

LogP

3.005300000000001

Topological Polar Surface Area

48.14 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

209

Synonyms & References

English

3-(benzyloxy)-5-bromopyridine-2-amine
2-Pyridinamine, 5-bromo-3-(phenylmethoxy)-
ZFNMAJBVWOHSSF-UHFFFAOYSA-N
J-510810
5-bromo-3-(phenylmethoxy)-2-Pyridinamine
5-bromo-3-phenylmethoxypyridin-2-amine
DS-11039
MFCD11109946
3-(benzyloxy)-5-bromopyridin-2-amine
2-amino-3-benzyloxy-5-bromo-pyridine
754230-78-9
CS-W004158
SY110306
SCHEMBL488302
FT-0649704
2-AMINO-5-BROMO-3-BENZYLOXYPYRIDINE
2-Amino-3-benzyloxy-5-bromopyridine
DTXSID50609168
A9608
AKOS015999725
3-Benzyloxy-5-bromo-pyridin-2-ylamine
2-Amino-5-bromo-3-benzyloxypyridine
3-Benzyloxy-5-bromo-2-pyridinamine
5-bromo-3-(phenylmethoxy)- 2-Pyridinamine
3-(Benzyloxy)-5-bromopyridin-2-amine
2-AMino-5-BroMo-3-Benzloxypyridine
KSC914C5F
1723AC
3-benzyloxy-5-bromo-pyridin-2-amine
2-amino-3-benzyloxy-5-bromo-pyr

MDL Number

MFCD11109946

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 3-benzyloxy-5-bromo-pyridin-2-amine (CAS: 754230-78-9)?

3-benzyloxy-5-bromo-pyridin-2-amine (CAS: 754230-78-9) is a crystalline solid with a molecular weight of approximately 348.14 g/mol. It is slightly soluble in water and more soluble in organic solvents like methanol and ethanol. The compound is relatively stable but can react with strong acids and bases. It exhibits basic properties due to the amine group.

How is 3-benzyloxy-5-bromo-pyridin-2-amine (CAS: 754230-78-9) typically synthesized?

3-benzyloxy-5-bromo-pyridin-2-amine (CAS: 754230-78-9) is typically synthesized through a multi-step process involving the bromination of pyridin-2-amine followed by the introduction of the benzyloxy group. Commonly used reagents include bromine and benzylic halides, with tert-butyldimethylsilyl chloride often used as a coupling agent. The yield is typically around 70-80%, with high selectivity for the desired product.

What industries use 3-benzyloxy-5-bromo-pyridin-2-amine (CAS: 754230-78-9)?

3-benzyloxy-5-bromo-pyridin-2-amine (CAS: 754230-78-9) is used in the pharmaceutical industry for developing new drug candidates, particularly in the synthesis of biologically active compounds. It also has potential applications in the sensor technology and semiconductor industries, where its chemical properties can be exploited for specific functionalities.

What precautions should be taken when handling 3-benzyloxy-5-bromo-pyridin-2-amine (CAS: 754230-78-9)?

Proper personal protective equipment (PPE) is essential when handling 3-benzyloxy-5-bromo-pyridin-2-amine (CAS: 754230-78-9). Wear gloves, safety goggles, and a lab coat to protect against skin and eye contact. Store the compound in a fume hood to avoid inhalation. In case of a spill, neutralize any acidic or basic reagents and then clean up according to the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS). Always handle the compound in a well-ventilated area to avoid exposure to fumes.