Compound Q&A

How is 3-benzyloxy-5-bromo-pyridin-2-amine (CAS: 754230-78-9) typically synthesized?

Answer

3-benzyloxy-5-bromo-pyridin-2-amine
3-benzyloxy-5-bromo-pyridin-2-amine (CAS: 754230-78-9) is typically synthesized through a multi-step process involving the bromination of pyridin-2-amine followed by the introduction of the benzyloxy group. Commonly used reagents include bromine and benzylic halides, with tert-butyldimethylsilyl chloride often used as a coupling agent. The yield is typically around 70-80%, with high selectivity for the desired product.

About

English Name 3-benzyloxy-5-bromo-pyridin-2-amine
Molecular Formula C12H11BrN2O
Molecular Weight 279.14 g/mol
SMILES C1=CC=C(C=C1)COC2=C(N=CC(=C2)Br)N
InChIKey ZFNMAJBVWOHSSF-UHFFFAOYSA-N
Last Updated: 2025-10-19 20:29

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