8-(Bromomethyl)quinoline

Basic Information

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CAS Number

7496-46-0

Molecular Formula

C10H8BrN

Molecular Weight

222.09 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

3261

Melting Point

81-82 ºC

Boiling Point

321.9 °C at 760 mmHg

Density

1.518

Flash Point

148.5 °C

Refractive Index

1.673

SMILES

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C1=CC2=C(C(=C1)CBr)N=CC=C2

InChI

InChI=1S/C10H8BrN/c11-7-9-4-1-3-8-5-2-6-12-10(8)9/h1-6H,7H2

InChIKey

IAAUGSYGHOFWEW-UHFFFAOYSA-N

LogP

3.1297000000000015

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

149

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H318 Causes serious eye damage
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

J-519347
EN300-25547
NSC405282
SMSSF-0625445
SY031624
SB71585
8-Bromomethyl-quinoline
Z211318946
8-Bromomethylquinoline
STR07370
A25902
AKOS001258536
DTXSID70323950
AC-22536
AMS_CNC_ID-1743832020
IAAUGSYGHOFWEW-UHFFFAOYSA-N
Quinoline, 8-(bromomethyl)-
MFCD00047621
FT-0621484
8-(Bromomethyl)quinoline
8-(bromo)methylquinoline
SCHEMBL243081
CS-W002233
NSC-405282
BCP07935
8-(Bromomethyl)quinoline, >=96.5% (GC)
8-Bromomethyl-quinoline;8-(Bromomethyl)quinoline
8-Quinolinylmethyl bromide
7496-46-0
AM20061483
KSC378K8N

MDL Number

MFCD00047621

Customs Code

2933499090

FAQ

What are the physical and chemical properties of 8-(Bromomethyl)quinoline (CAS: 7496-46-0)?

8-(Bromomethyl)quinoline (CAS: 7496-46-0) is a yellow crystalline solid with a molecular weight of approximately 229.04 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can react with reducing agents. The compound has a melting point of 128-130°C.

How is 8-(Bromomethyl)quinoline (CAS: 7496-46-0) typically synthesized?

8-(Bromomethyl)quinoline can be synthesized via the reaction of 8-hydroxyquinoline with phosphorous tribromide. The process involves the substitution of the hydroxyl group with a bromomethyl group, providing high selectivity and yield. Commonly used catalysts and conditions ensure efficient conversion and purification.

What industries use 8-(Bromomethyl)quinoline (CAS: 7496-46-0)?

8-(Bromomethyl)quinoline (CAS: 7496-46-0) is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the development of sensors and as an intermediate in the production of dyes and pigments. Additionally, its unique properties make it useful in the semiconductor industry for specific applications.

What precautions should be taken when handling 8-(Bromomethyl)quinoline (CAS: 7496-46-0)?

When handling 8-(Bromomethyl)quinoline (CAS: 7496-46-0), appropriate personal protective equipment (PPE) should be worn, including gloves, safety glasses, and a lab coat. The compound should be handled in a well-ventilated fume hood to minimize exposure. Spills should be managed carefully using appropriate absorbents, and the area should be thoroughly cleaned. Always refer to the Safety Data Sheet (SDS) for detailed safety information and guidelines.