5-Bromo-3-fluoro-2-pyridinamine

Basic Information

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CAS Number

748812-37-5

Molecular Formula

C5H4BrFN2

Molecular Weight

191 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

94-96°C

Flash Point

73.7℃

SMILES

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C1=C(C=NC(=C1F)N)Br

InChI

InChI=1S/C5H4BrFN2/c6-3-1-4(7)5(8)9-2-3/h1-2H,(H2,8,9)

InChIKey

QLXASFJHUCKEHU-UHFFFAOYSA-N

LogP

1.5654000000000001

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

101

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AS-18533
DTXSID00678869
AKOS005063874
EN300-117728
QLXASFJHUCKEHU-UHFFFAOYSA-N
MFCD11848483
A850117
748812-37-5
5-bromo-3-fluoro-2-pyridinamine
SB18619
FT-0763285
AU-004/43508269
2-AMINO-5-BROMO-3-FLUOROPYRIDINE
SCHEMBL502604
Z1255491677
5-Bromo-3-fluoropyridin-2-amine
5-Bromo-3-fluoro-pyridin-2-ylamine
CS-W018605
SY014399
AM62485
2-Amino-5-bromo-3-fluoropyridine
PubChem20322
3-Fluoro-5-bromopyridine-2-amine
5-bromo-3-fluoro-pyridin-2-amine
BBL103622
STL557432
2-Pyridinamine, 5-bromo-3-fluoro-
RP03741
VP15016
BC236256
BC

MDL Number

MFCD11848483

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 5-Bromo-3-fluoro-2-pyridinamine (CAS: 748812-37-5)?

5-Bromo-3-fluoro-2-pyridinamine is a crystalline solid with a molecular weight of approximately 213.03 g/mol. It is slightly soluble in water and moderately soluble in common organic solvents. The compound is reactive towards nucleophilic reagents and can undergo substitution reactions. It is stable under normal conditions but should be stored in a dry environment to prevent hydrolysis.

How is 5-Bromo-3-fluoro-2-pyridinamine (CAS: 748812-37-5) typically synthesized?

5-Bromo-3-fluoro-2-pyridinamine is synthesized through a multistep process involving the bromination and fluorination of 2-pyridinamine. Commonly, this involves the use of N-bromosuccinimide (NBS) as a brominating agent and fluoroform as a fluorinating agent. The reaction is typically carried out in the presence of an appropriate solvent, and the product is purified using recrystallization or column chromatography.

What industries use 5-Bromo-3-fluoro-2-pyridinamine (CAS: 748812-37-5)?

5-Bromo-3-fluoro-2-pyridinamine finds applications in the pharmaceutical industry for the synthesis of certain compounds. It is also used in the development of sensors and in the production of semiconductors due to its chemical reactivity and specific functional groups.

What precautions should be taken when handling 5-Bromo-3-fluoro-2-pyridinamine (CAS: 748812-37-5)?

When handling 5-Bromo-3-fluoro-2-pyridinamine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of vapors. Spills should be handled with appropriate absorbent materials, and the area should be thoroughly cleaned. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.