How is 5-Bromo-3-fluoro-2-pyridinamine (CAS: 748812-37-5) typically synthesized?

5-Bromo-3-fluoro-2-pyridinamine is synthesized through a multistep process involving the bromination and fluorination of 2-pyridinamine. Commonly, this involves the use of N-bromosuccinimide (NBS) as a brominating agent and fluoroform as a fluorinating agent. The reaction is typically carried out in the presence of an appropriate solvent, and the product is purified using recrystallization or column chromatography.