(R)-(+)-2-Chloropropionic Acid

Basic Information

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CAS Number

7474-05-7

Molecular Formula

C3H5ClO2

Molecular Weight

108.52 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Water Treatment Chemicals Disinfectants Chlorine Compounds

Basic Physical Properties

Melting Point

-12°C

Boiling Point

185-188 °C

Density

1.258 g/mL at 20 °C

Refractive Index

n20/D 1.4345(lit.)

Specific Rotation

14 º (neat)

SMILES

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CC(C(=O)O)Cl

InChI

InChI=1S/C3H5ClO2/c1-2(4)3(5)6/h2H,1H3,(H,5,6)/t2-/m1/s1

InChIKey

GAWAYYRQGQZKCR-UWTATZPHSA-N

LogP

0.6983

Topological Polar Surface Area

37.3 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

61.8

Safety Information

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Hazard Statement

H290 May be corrosive to metals
Corrosive to Metals

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Synonyms & References

English

(R)-2-Chloropropanoic acid
(R)-.ALPHA.-CHLOROPROPIONIC ACID
BCP14313
MFCD00064204
Propionic acid, 2-chloro-, D-
UNII-F60ST8319R
D-Chloropropionic acid
GAWAYYRQGQZKCR-UWTATZPHSA-N
.ALPHA.-CHLOROPROPIONIC ACID, (+)-
(+)-2-chloropropionic acid
Propanoic acid, 2-chloro-, (R)-
SCHEMBL852065
(2R)-2-chloropropanoic acid
(R)-2-chloro-propionic acid
(2R)-2-CHLOROPROPIONIC ACID
AM81430
F16436
RCI
Propanoic acid, 2-chloro-, (2R)-
D-2-Chloropropanoic acid
(R)-2-Chloropropionic acid
(+)-2-Chloropropanoic acid
7474-05-7
(+)-.ALPHA.-CHLOROPROPANOIC ACID
28554-00-9
EN300-311683
MS-20652
CS-0022394
F60ST8319R
(2R)-(+)-2-Chloropropanoic acid
2-Chloropropionic acid, (+)-

MDL Number

MFCD00064204

Customs Code

2915900090

FAQ

What are the physical and chemical properties of (R)-(+)-2-Chloropropionic Acid (CAS: 7474-05-7)?

(R)-(+)-2-Chloropropionic Acid is a white crystalline solid with a molecular weight of approximately 132.54 g/mol. It has a pKa of 2.3 and is slightly soluble in water. The compound is reactive, showing good reactivity towards nucleophiles and electrophiles. It is commonly used in organic synthesis and pharmaceuticals due to its chirality and reactivity.

How is (R)-(+)-2-Chloropropionic Acid (CAS: 7474-05-7) typically synthesized?

(R)-(+)-2-Chloropropionic Acid can be synthesized via asymmetric synthesis using chiral pools or chiral auxiliaries. Common methods include the reaction of (R)-2-bromopropionic acid with sodium hypochlorite in the presence of a base. This reaction provides good yield and enantioselectivity, making it a preferred method for industrial production.

What industries use (R)-(+)-2-Chloropropionic Acid (CAS: 7474-05-7)?

(R)-(+)-2-Chloropropionic Acid is primarily used in the pharmaceutical and chemical industries. It serves as a precursor in the synthesis of chiral intermediates and drug candidates. Due to its reactivity, it is also used in the development of new polymers and in the production of chiral sensing materials and semiconductors.

What precautions should be taken when handling (R)-(+)-2-Chloropropionic Acid (CAS: 7474-05-7)?

When handling (R)-(+)-2-Chloropropionic Acid, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up carefully and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.