(R)-(+)-2-Chloropropionic Acid(CAS: 7474-05-7)

(R)-(+)-2-Chloropropionic Acid is a white crystalline solid with a molecular weight of approximately 132.54 g/mol. It has a pKa of 2.3 and is slightly soluble in water. The compound is reactive, showing good reactivity towards nucleophiles and electrophiles. It is commonly used in organic synthesis and pharmaceuticals due to its chirality and reactivity.

(R)-(+)-2-Chloropropionic Acid can be synthesized via asymmetric synthesis using chiral pools or chiral auxiliaries. Common methods include the reaction of (R)-2-bromopropionic acid with sodium hypochlorite in the presence of a base. This reaction provides good yield and enantioselectivity, making it a preferred method for industrial production.

(R)-(+)-2-Chloropropionic Acid is primarily used in the pharmaceutical and chemical industries. It serves as a precursor in the synthesis of chiral intermediates and drug candidates. Due to its reactivity, it is also used in the development of new polymers and in the production of chiral sensing materials and semiconductors.

When handling (R)-(+)-2-Chloropropionic Acid, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up carefully and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.