(5-Chloro-2-thienyl)methanol

Basic Information

View in Editor

CAS Number

74168-69-7

Molecular Formula

C5H5ClOS

Molecular Weight

148.61 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

160℃/20Torr

SMILES

View in Editor

C1=C(SC(=C1)Cl)CO

InChI

InChI=1S/C5H5ClOS/c6-5-2-1-4(3-7)8-5/h1-2,7H,3H2

InChIKey

WMKPGPCVKFXIHD-UHFFFAOYSA-N

LogP

1.8938000000000001

Topological Polar Surface Area

20.23 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

78.8

Synonyms & References

English

(5-chloro-2-thienyl)methanol
DTXSID00502337
2-Thiophenemethanol, 5-chloro-
74168-69-7
(5-Chlorothiophen-2-yl)methanol
SY021686
5-CHLOROTHIOPHENE-2-METHANOL
Z381678198
5-chlorothiophen-2-ylmethyl alcohol
CS-0053152
5-Chloro-2-thiophenemethanol
5-chloro-2-thiophene-methanol
AKOS008077848
PB23436
Propionic acid, b,b'-(methylimino)di-, diethyl ester
WMKPGPCVKFXIHD-UHFFFAOYSA-N
5-Chlorothiophene-2-ylmethanol
5-CHLOROTHIOPHEN-2-YLMETHANOL
FT-0653784
SCHEMBL282133
AS-31229
MFCD06202649
C5H5ClOS
J-517422
ZCA16869
A838041
EN300-54914
2-(Hydroxymethyl)-5-chlorothiophene
(5-chloro-2-thienyl) methanol
5-Chloro-2-thienylmethanol
5-Chlorothiophen-2-ylmethanol

MDL Number

MFCD06202649

Customs Code

2934999090

FAQ

What are the physical and chemical properties of (5-Chloro-2-thienyl)methanol (CAS: 74168-69-7)?

(5-Chloro-2-thienyl)methanol (CAS: 74168-69-7) is a crystalline solid with a molecular weight of approximately 189.02 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is reactive towards nucleophiles and can participate in electrophilic substitution reactions due to the presence of the thienyl ring and chlorine substituent.

How is (5-Chloro-2-thienyl)methanol (CAS: 74168-69-7) typically synthesized?

(5-Chloro-2-thienyl)methanol is typically synthesized via a multistep process involving the reaction of 2-chlorothiophene with methanol in the presence of a suitable base like sodium methoxide. The reaction is carried out in an aprotic solvent to avoid side reactions. The yield is usually around 60-70%, and the product is purified by recrystallization.

What industries use (5-Chloro-2-thienyl)methanol (CAS: 74168-69-7)?

(5-Chloro-2-thienyl)methanol finds applications in the pharmaceutical industry as a precursor for synthesizing various drug molecules. It is also used in the polymer industry for the development of advanced materials and in the sensor and semiconductor industries for specific functional groups that can enhance material properties.

What precautions should be taken when handling (5-Chloro-2-thienyl)methanol (CAS: 74168-69-7)?

When handling (5-Chloro-2-thienyl)methanol (CAS: 74168-69-7), it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. It should be stored in a closed container away from heat and ignition sources. In case of a spill, use appropriate spill cleanup procedures and ensure proper disposal. Always refer to the safety data sheet (SDS) for detailed information on safe handling and emergency procedures.