4-[(4-Bromobenzyl)oxy]quinazoline

Basic Information

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CAS Number

737818-56-3

Molecular Formula

C15H11BrN2O

Molecular Weight

315.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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c1ccc2c(c1)c(ncn2)OCc3ccc(cc3)Br

InChI

InChI=1S/C15H11BrN2O/c16-12-7-5-11(6-8-12)9-19-15-13-3-1-2-4-14(13)17-10-18-15/h1-8,10H,9H2

InChIKey

DADJIQURPZZXBT-UHFFFAOYSA-N

LogP

3.971300000000001

Topological Polar Surface Area

35.010000000000005 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Synonyms & References

English

Quinazoline, 4-[(4-bromophenyl)methoxy]-
WAY-340935
VEGFR2-IN-2

MDL Number

MFCD03983874

FAQ

What are the physical and chemical properties of 4-[(4-Bromobenzyl)oxy]quinazoline (CAS: 737818-56-3)?

4-[(4-Bromobenzyl)oxy]quinazoline (CAS: 737818-56-3) is a crystalline solid with a molecular weight of approximately 354.05 g/mol. It has a melting point of around 210-212°C and is poorly soluble in water but soluble in organic solvents like dichloromethane and methanol. Chemically, it is less reactive towards common acids and bases but can undergo nucleophilic substitution reactions. It is stable under normal laboratory conditions but should be stored in a cool, dry place away from direct sunlight.

How is 4-[(4-Bromobenzyl)oxy]quinazoline (CAS: 737818-56-3) typically synthesized?

4-[(4-Bromobenzyl)oxy]quinazoline (CAS: 737818-56-3) is typically synthesized via a multi-step process involving the reaction of quinazoline with 4-bromobenzyl alcohol. The synthesis involves protecting the amine group, followed by a coupling reaction and deprotection. The overall reaction yields approximately 60-70% of the target compound, and the process is conducted under mild conditions using catalytic amounts of a suitable reagent. Proper workup and purification techniques are necessary to isolate the final product.

What industries use 4-[(4-Bromobenzyl)oxy]quinazoline (CAS: 737818-56-3)?

4-[(4-Bromobenzyl)oxy]quinazoline (CAS: 737818-56-3) is used in a variety of industries, including pharmaceuticals, where it serves as a potential intermediate in drug synthesis. It also finds applications in the development of sensors and semiconductors due to its unique chemical properties. The compound's ability to participate in specific reactions makes it valuable in the research and development of new materials and pharmaceuticals.

What precautions should be taken when handling 4-[(4-Bromobenzyl)oxy]quinazoline (CAS: 737818-56-3)?

When handling 4-[(4-Bromobenzyl)oxy]quinazoline (CAS: 737818-56-3), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up promptly using appropriate absorbents, and the area should be well-ventilated. It is crucial to have a Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) readily available in case of any emergencies. Storage should be in a cool, dry place away from direct sunlight and flammable materials.