N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threonine hydrate (1:1)

Basic Information

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CAS Number

73731-37-0

Molecular Formula

C19H21NO6

Molecular Weight

341.36 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

115°C

Boiling Point

596.5°C at 760 mmHg

Density

1.3270

Flash Point

No data available

Refractive Index

-15.5 ° (C=1, DMF)

Vapor Pressure

No data available

Specific Rotation

-16 º (c=1%, DMF)

SMILES

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CC(C(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)O

InChI

InChI=1S/C19H19NO5.H2O/c1-11(21)17(18(22)23)20-19(24)25-10-16-14-8-4-2-6-12(14)13-7-3-5-9-15(13)16;/h2-9,11,16-17,21H,10H2,1H3,(H,20,24)(H,22,23);1H2/t11-,17+;/m1./s1

InChIKey

CGNQPFAECJFQNV-NRNQBQMASA-N

LogP

2.3590999999999998

Topological Polar Surface Area

95.86000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 6

Complexity

474

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(2S,3R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-oxidanyl-butanoic acid
FMOC-L-THREONINE
Nalpha-(9-Fluorenylmethoxycarbonyl)-L-threonine
CS-W009412
Fmoc-Thr-OH.nH2O
N-(9-Fluorenylmethoxycarbonyl)threonine
O11819
Z1227754900
(2S,3R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxybutanoic acid
EN300-81295
N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-THREONINE
AM20041096
73731-37-0
(2S,3R)-2-(((9H-FLUOREN-9-YL)METHOXY)CARBONYLAMINO)-3-HYDROXYBUTANOIC ACID
(2S,3R)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-hydroxybutanoic acid
M03388
AKOS015837088
Fmoc-Thr-OH
AKOS015895366
SCHEMBL2551441
AS-50298
HY-W008696
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threonine
MFCD00077072
N-Fmoc-L-threonine
OYULCCKKLJPNPU-DIFFPNOSSA-N
2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-butanoic acid
F0455
(2S,3R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxybutanoic acid
(2S,3R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-hydroxybutanoic acid
A837911

MDL Number

MFCD00077072

Customs Code

2924299090

FAQ

What are the physical and chemical properties of N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threonine hydrate (CAS: 73731-37-0)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threonine hydrate (CAS: 73731-37-0) is a white crystalline powder with a molecular weight of approximately 525.45 g/mol. It is sparingly soluble in water and has a low reactivity under normal conditions. This compound is known for its stability and can be used in various organic synthesis reactions.

How is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threonine hydrate (CAS: 73731-37-0) typically synthesized?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threonine hydrate (CAS: 73731-37-0) is typically synthesized through the carbonylation of L-threonine using fluorenylmethanol as the protecting group. The reaction involves the formation of a fluorenylmethoxycarbonyl (Fmoc) derivative, followed by the removal of the Fmoc group to yield the desired product with high yield and selectivity.

What industries use N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threonine hydrate (CAS: 73731-37-0)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threonine hydrate (CAS: 73731-37-0) is primarily used in the pharmaceutical and chemical industries for the synthesis of various organic compounds. It is also utilized in the preparation of polymers and in the development of advanced materials due to its chemical stability and reactivity.

What precautions should be taken when handling N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threonine hydrate (CAS: 73731-37-0)?

When handling N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threonine hydrate (CAS: 73731-37-0), it is important to use personal protective equipment such as gloves, safety goggles, and a lab coat. Work in a well-ventilated area or fume hood to avoid inhalation of dust or vapor. Store the compound in a cool, dry place, away from direct sunlight and heat sources. Always refer to the Safety Data Sheet (SDS) for more detailed safety information.