1H-Indazol-3-ol

Basic Information

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CAS Number

7364-25-2

Molecular Formula

C7H6N2O

Molecular Weight

134.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

247.0 to 251.0 deg-C

Boiling Point

247.23°C (rough estimate)

Density

1.2296 (rough estimate)

Flash Point

88.3 °C

Refractive Index

1.5880 (estimate)

SMILES

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C1=CC=C2C(=C1)C(=O)NN2

InChI

InChI=1S/C7H6N2O/c10-7-5-3-1-2-4-6(5)8-9-7/h1-4H,(H2,8,9,10)

InChIKey

SWEICGMKXPNXNU-UHFFFAOYSA-N

LogP

0.8562

Topological Polar Surface Area

48.65 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

158

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

2H-Indazol-3-ol
SY325041
Q27270248
SWEICGMKXPNXNU-UHFFFAOYSA-
NSC-9352
NSC9352
1,2-Dihydro-indazol-3-one
MFCD00005685
Benzopyrazol-3-
2,3-Dihydro-1H-indazol-3-one
C71048
NS00044242
3-Indazolinone;3-Oxo-2,3-dihydro-1H-indazole
EN300-49155
s10203
CCRIS 6800
DTXSID2049428
3-Indazolone
3H-Indazol-3-one,2-dihydro-
CS-W013384
InChI=1/C7H6N2O/c10-7-5-3-1-2-4-6(5)8-9-7/h1-4H,(H2,8,9,10)
MFCD00234274
SCHEMBL276725
UNII-8E254S9S1R
AKOS009157211
3-Oxo-1,2-indazole
Z586248764
NCGC00260489-01
8E254S9S1R
A897296
3-Indazolinone

MDL Number

MFCD00005685

FAQ

What are the physical and chemical properties of 1H-Indazol-3-ol (CAS: 7364-25-2)?

1H-Indazol-3-ol (CAS: 7364-25-2) is a crystalline solid with a molecular weight of approximately 135.14 g/mol. It has a low solubility in water but dissolves well in organic solvents like methanol and ethanol. Chemically, it is relatively stable but can undergo dehydrogenation and cyclization under certain conditions. It has a pKa of around 5.2, indicating basic properties.

How is 1H-Indazol-3-ol (CAS: 7364-25-2) typically synthesized?

1H-Indazol-3-ol can be synthesized via the condensation of indole-3-carbaldehyde with hydrazine, followed by hydrolysis. A more common route involves the reaction of indole-3-carboxaldehyde with ammonia to form indazole-3-carboxamide, which is then hydrolyzed to yield 1H-Indazol-3-ol. Detailed procedures often use mild base conditions to promote the condensation and hydrolysis steps.

What industries use 1H-Indazol-3-ol (CAS: 7364-25-2)?

1H-Indazol-3-ol (CAS: 7364-25-2) is primarily used in pharmaceuticals for the synthesis of various bioactive compounds. It also finds applications in the development of sensors and semiconductors. Due to its structural complexity, it is also utilized in polymer chemistry for modifying and enhancing the properties of polymers.

What precautions should be taken when handling 1H-Indazol-3-ol (CAS: 7364-25-2)?

When handling 1H-Indazol-3-ol (CAS: 7364-25-2), it is important to wear appropriate personal protective equipment (PPE), including gloves and goggles, to protect against skin and eye contact. Store it in a dry, cool place away from direct sunlight and flammable materials. In case of a spill, neutralize any acidic or basic compounds and rinse with water. Always refer to the Safety Data Sheet (SDS) for detailed instructions and emergency procedures.