1H-Indazol-3-ol(CAS: 7364-25-2)

1H-Indazol-3-ol (CAS: 7364-25-2) is a crystalline solid with a molecular weight of approximately 135.14 g/mol. It has a low solubility in water but dissolves well in organic solvents like methanol and ethanol. Chemically, it is relatively stable but can undergo dehydrogenation and cyclization under certain conditions. It has a pKa of around 5.2, indicating basic properties.

1H-Indazol-3-ol can be synthesized via the condensation of indole-3-carbaldehyde with hydrazine, followed by hydrolysis. A more common route involves the reaction of indole-3-carboxaldehyde with ammonia to form indazole-3-carboxamide, which is then hydrolyzed to yield 1H-Indazol-3-ol. Detailed procedures often use mild base conditions to promote the condensation and hydrolysis steps.

1H-Indazol-3-ol (CAS: 7364-25-2) is primarily used in pharmaceuticals for the synthesis of various bioactive compounds. It also finds applications in the development of sensors and semiconductors. Due to its structural complexity, it is also utilized in polymer chemistry for modifying and enhancing the properties of polymers.

When handling 1H-Indazol-3-ol (CAS: 7364-25-2), it is important to wear appropriate personal protective equipment (PPE), including gloves and goggles, to protect against skin and eye contact. Store it in a dry, cool place away from direct sunlight and flammable materials. In case of a spill, neutralize any acidic or basic compounds and rinse with water. Always refer to the Safety Data Sheet (SDS) for detailed instructions and emergency procedures.