(2E)-3-(2-Pyridinyl)acrylic acid

Basic Information

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CAS Number

7340-22-9

Molecular Formula

C8H7NO2

Molecular Weight

149.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

201-203°C

Boiling Point

304.8℃ at 760 mmHg

Flash Point

138.1℃

SMILES

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C1=CC=NC(=C1)C=CC(=O)O

InChI

InChI=1S/C8H7NO2/c10-8(11)5-4-7-3-1-2-6-9-7/h1-6H,(H,10,11)/b5-4+

InChIKey

LKDFTXDJKHGCAC-SNAWJCMRSA-N

LogP

1.1794

Topological Polar Surface Area

50.19 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

166

Safety Information

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Hazard Statement

Synonyms & References

English

54495-51-1
CS-W021780
2-Pyridineacrylic acid
EN300-42627
3-(2-pyridyl)acrylic acid, AldrichCPR
A837822
(E)-3-pyridin-2-yl acrylic acid
7340-22-9
E-3-(2-pyridyl)propenoic acid
(E)-3-(PYRIDIN-2-YL)ACRYLICACID
AB01329936-02
3-(2-Pyridyl)acrylic acid
3-Pyridin-2-yl-acrylic acid
EN300-1455843
(e)-3-pyridin-2-yl-acrylic acid
NS00044589
NSC63239
2-(2-Carboxyvinyl)pyridine, trans
(E)-3-(PYRIDIN-2-YL)ACRYLIC ACID
3-(2-Pyridyl)acrylic Acid (Predominantly trans)
NSC-63239
AKOS000148385
CS-11332
Z57069085
(E)-3-(2-pyridinyl)-2-propenoic acid
trans-3-(pyridinyl)acrylic acid
3-(Pyridin-2-yl)prop-2-enoic acid
3-(2-Pyridyl)acrylic Acid, Predominantly trans
3-pyridin-2-ylacrylic acid
NCGC00336228-01
MFCD00179422

MDL Number

MFCD00179422

Customs Code

2933399090

FAQ

What are the physical and chemical properties of (2E)-3-(2-Pyridinyl)acrylic acid (CAS: 7340-22-9)?

(2E)-3-(2-Pyridinyl)acrylic acid is a white crystalline solid with a molecular weight of approximately 152.18 g/mol. It has a pKa of about 3.8 and is slightly soluble in water. This compound is known for its reactivity towards nucleophiles and can undergo condensation reactions. It is stable under normal conditions but may decompose at elevated temperatures.

How is (2E)-3-(2-Pyridinyl)acrylic acid (CAS: 7340-22-9) typically synthesized?

(2E)-3-(2-Pyridinyl)acrylic acid can be synthesized by reacting 2-pyridylacetaldehyde with acryloyl chloride in the presence of a base like triethylamine. The reaction is typically conducted at room temperature, yielding a product with high selectivity and a good yield of around 80%.

What industries use (2E)-3-(2-Pyridinyl)acrylic acid (CAS: 7340-22-9)?

(2E)-3-(2-Pyridinyl)acrylic acid is widely used in the pharmaceutical industry for the synthesis of certain drugs and as a precursor in the production of polymers. It is also utilized in the development of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling (2E)-3-(2-Pyridinyl)acrylic acid (CAS: 7340-22-9)?

When handling (2E)-3-(2-Pyridinyl)acrylic acid, wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize exposure to vapors. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.