(2E)-3-(2-Pyridinyl)acrylic acid(CAS: 7340-22-9)

(2E)-3-(2-Pyridinyl)acrylic acid is a white crystalline solid with a molecular weight of approximately 152.18 g/mol. It has a pKa of about 3.8 and is slightly soluble in water. This compound is known for its reactivity towards nucleophiles and can undergo condensation reactions. It is stable under normal conditions but may decompose at elevated temperatures.

(2E)-3-(2-Pyridinyl)acrylic acid can be synthesized by reacting 2-pyridylacetaldehyde with acryloyl chloride in the presence of a base like triethylamine. The reaction is typically conducted at room temperature, yielding a product with high selectivity and a good yield of around 80%.

(2E)-3-(2-Pyridinyl)acrylic acid is widely used in the pharmaceutical industry for the synthesis of certain drugs and as a precursor in the production of polymers. It is also utilized in the development of sensors and semiconductors due to its unique chemical properties.

When handling (2E)-3-(2-Pyridinyl)acrylic acid, wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize exposure to vapors. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.