Aciclovir (Acyclovir) EP Impurity B (Valaciclovir EP Impurity B)

Basic Information

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CAS Number

73-40-5

Molecular Formula

C5H5N5O

Molecular Weight

151.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

>300 °C

Boiling Point

273.11°C (rough estimate)

Density

1.4456 (rough estimate)

Flash Point

311.4 °C

Solubility

1 M NaOH: 0.1 M at 20 °C, clear, colorless

Refractive Index

2.0000 (estimate)

SMILES

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Nc1nc2[nH]cnc2c(=O)[nH]1

InChI

InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)

InChIKey

UYTPUPDQBNUYGX-UHFFFAOYSA-N

LogP

-0.7716000000000003

pKa

9.92(at 40℃)

Topological Polar Surface Area

100.44999999999999 Å²

Hydrogen Bond Donor/Acceptor

4 / 6

Complexity

225

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Storage Conditions

2-8℃

Stability

Stable. Incompatible with strong oxidizing agents.

Synonyms & References

English

2-Amino-1H-purin-6(7H)-one
2-Amino-1,7-dihydro-6H-purin-6-one
2-Aminohypoxanthine
2-Amino-6-hydroxypurine
Guanine
GUANINE(Anhydrous)(RG)
2-amino-1,9-dihydro-6H-purin-6-one
2-amino-6-oxypurine
dewpearl
Gua
guamine
Guanie
Guanin
IMidoxanthin
quanine
Mearlmaid
Pearl essence
Guanine enol
Stella Polaris
Dew Pearl
Natural pearl essence
Natural white 1
2-Amino-6-purinol
C.I. Natural White 1
CI Natural white 1
6H-Purin-6-one, 2-amino-1,7-dihydro-
Hypoxanthine, 2-amino-
6-Hydroxy-2-aminopurine
2-amino-9H-purin-6-ol
C.I. 75170
Mearlmaid AA

MDL Number

MFCD00071533

Customs Code

29335990

FAQ

What is Aciclovir (Acyclovir) EP Impurity B (CAS: 73-40-5)?

Aciclovir (Acyclovir) EP Impurity B, with the CAS number 73-40-5, is a chemical compound that serves as an impurity in the production of valaciclovir, an antiviral drug used to treat herpes infections. It is a white crystalline powder with a molecular formula of C8H12N2O3 and is known for its solubility in water and organic solvents. This compound is often analyzed during quality control processes to ensure the purity of the final pharmaceutical product.

What are the main uses of Aciclovir (Acyclovir) EP Impurity B (CAS: 73-40-5)?

Aciclovir (Acyclovir) EP Impurity B is primarily used in the pharmaceutical industry as an impurity marker during the production and quality control of valaciclovir. It helps in identifying and quantifying impurities that may arise during synthesis, ensuring the safety and efficacy of the final drug. Additionally, it is used in research for studying the purity and stability of antiviral compounds.

Is Aciclovir (Acyclovir) EP Impurity B (CAS: 73-40-5) safe?

Aciclovir (Acyclovir) EP Impurity B is generally considered safe when handled in accordance with standard laboratory and industrial safety protocols. However, as an impurity, it may have unknown toxicological properties, so appropriate protective measures such as gloves and safety goggles should be used during handling. It is important to follow safety data sheet guidelines and ensure proper disposal to minimize any potential risks.

How should Aciclovir (Acyclovir) EP Impurity B (CAS: 73-40-5) be stored?

Aciclovir (Acyclovir) EP Impurity B should be stored in a cool, dry, and well-ventilated place, away from direct light. It is typically kept in a sealed container at a temperature range of 15–25°C. Maintaining low humidity levels is also crucial to prevent degradation. Proper storage ensures the stability and integrity of the compound during handling and analysis.