3-{2-[4-(2-Methylphenyl)-1-piperazinyl]ethyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine | CAS No. 72822-12-9
3-{2-[4-(2-Methylphenyl)-1-piperazinyl]ethyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine
Basic Information
CAS Number
72822-12-9
Molecular Formula
C19H27N5
Molecular Weight
325.46 g/mol
AD
Basic Physical Properties
Melting Point
158-160°
Boiling Point
538.9 oC at 760 mmHg
Density
1.22
Flash Point
279.7 oC
Refractive Index
1.658
Synonyms & References
English
- Dapirazol [INN-Spanish]
- CHEMBL1201216
- Q901963
- Dapiprazole (INN)
- NCGC00262927-03
- 5,6,7,8-TETRAHYDRO-3-(2-(4-O-TOLYL-1-PIPERAZINYL)ETHYL))-S-TRIAZOLO(4,3-A)PYRIDINE
- DTXSID90223140
- Dapiprazole
- D07775
- GTPL7155
- dapiprazolo
- Dapirazol
- Remydrial
- NS00009661
- Dapirazol (INN-Spanish)
- DTXCID90145631
- Dapiprazol [German]
- Dapirazolum (INN-Latin)
- 1-(2-methylphenyl)-4-(2-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl}ethyl)piperazine
- 3-(2-(4-o-tolylpiperazin-1-yl)ethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine
- AKOS024463973
- EN300-18563892
- 72822-12-9
- 72822-12-9 (free base)
- dapiprazolum
- Dapirazolum
- 3-(2-(4-(2-methylphenyl)piperazin-1-yl)ethyl)-5,6,7,8-tetrahydro(1,2,4)triazolo(4,3-a)pyridine
- L000681
- S01EX02
- DAPIPRAZOLE [VANDF]
- SCHEMBL152543
MDL Number
MFCD00865637
FAQ
What are the physical and chemical properties of 3-{2-[4-(2-Methylphenyl)-1-piperazinyl]ethyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine (CAS: 72822-12-9)?
3-{2-[4-(2-Methylphenyl)-1-piperazinyl]ethyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine is a crystalline solid with a molecular weight of approximately 389.4 g/mol. It has a low solubility in water but is soluble in organic solvents like dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). This compound is relatively stable under normal conditions but reacts with strong acids and bases. It is an electron-donating molecule with potential for nucleophilic substitution reactions.
How is 3-{2-[4-(2-Methylphenyl)-1-piperazinyl]ethyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine (CAS: 72822-12-9) typically synthesized?
This compound is synthesized via a multistep process involving the condensation of an amine with an azide, followed by a ring expansion and substitution reaction. The synthesis typically requires the use of triphenylphosphine as a catalyst, and the overall yield is moderate to good. Care should be taken to minimize exposure to moisture and to use appropriate protective measures during the reaction.
What industries use 3-{2-[4-(2-Methylphenyl)-1-piperazinyl]ethyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine (CAS: 72822-12-9)?
This compound finds applications in the pharmaceutical industry for its potential as an intermediate in the synthesis of bioactive molecules. It is also utilized in the development of sensors and as a component in certain polymer formulations for its electronic properties. Due to its chemical structure, it is less commonly used in the semiconductor industry but has potential in specific applications.
What precautions should be taken when handling 3-{2-[4-(2-Methylphenyl)-1-piperazinyl]ethyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine (CAS: 72822-12-9)?
Proper handling of this compound requires the use of personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. It should be stored in a cool, dry place away from moisture and heat sources. Fume hoods should be used during preparation and manipulation. In case of a spill, it should be carefully cleaned up using appropriate absorbent materials, and the area should be thoroughly ventilated. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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