Compound Q&A

How is 3-{2-[4-(2-Methylphenyl)-1-piperazinyl]ethyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine (CAS: 72822-12-9) typically synthesized?

Answer

3-{2-[4-(2-Methylphenyl)-1-piperazinyl]ethyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine
This compound is synthesized via a multistep process involving the condensation of an amine with an azide, followed by a ring expansion and substitution reaction. The synthesis typically requires the use of triphenylphosphine as a catalyst, and the overall yield is moderate to good. Care should be taken to minimize exposure to moisture and to use appropriate protective measures during the reaction.

About

CAS No 72822-12-9
English Name 3-{2-[4-(2-Methylphenyl)-1-piperazinyl]ethyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine
Molecular Formula C19H27N5
Molecular Weight 325.46 g/mol
SMILES CC1=CC=CC=C1N2CCN(CC2)CCC3=NN=C4N3CCCC4
InChIKey RFWZESUMWJKKRN-UHFFFAOYSA-N
Last Updated: 2026-03-07 15:41

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