(5-Chloro-2-pyrazinyl)methanol

Basic Information

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CAS Number

72788-94-4

Molecular Formula

C5H5ClN2O

Molecular Weight

144.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Melting Point

62-63 ºC

Boiling Point

255.7±35.0 ºC (760 Torr),

Density

1.422±0.06 g/cm3 (20 ºC 760 Torr),

Flash Point

108.5±25.9 ºC,

SMILES

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C1=C(N=CC(=N1)Cl)CO

InChI

InChI=1S/C5H5ClN2O/c6-5-2-7-4(3-9)1-8-5/h1-2,9H,3H2

InChIKey

YUTQYZGRAJOIJV-UHFFFAOYSA-N

LogP

0.6223

Topological Polar Surface Area

46.010000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AKOS006307693
2-Hydroxymethyl-5-chloropyrazine
SY029707
DTXSID50634379
FT-0707102
EN300-105691
AC-27249
Pyrazinemethanol, 5-chloro-
72788-94-4
J-501573
MFCD11110224
(5-chloro-2-pyrazinyl)methanol
DS-1551
2-Chloro-5-(hydroxymethyl)pyrazine
YUTQYZGRAJOIJV-UHFFFAOYSA-N
SCHEMBL507699
CS-W003772
5-CHLORO-2-PYRAZINEMETHANOL
PB20569
Z1198313424
(5-chloranylpyrazin-2-yl)methanol
(5-Chloropyrazin-2-yl)methanol
A837619
AM20070384
(3-amino-5-chloropyrazin-2-yl)methanol
2-HYDROXYMETHYL-5-CHLOROPYRAZINE
5-chloro-2-Pyrazinemethanol
2-pyrazinemethanol, 5-chloro-
C90112
(5-Chloro-2-pyrazinyl)methanol
PubChem23492

MDL Number

MFCD11110224

FAQ

What are the physical and chemical properties of (5-Chloro-2-pyrazinyl)methanol (CAS: 72788-94-4)?

(5-Chloro-2-pyrazinyl)methanol is a crystalline solid with a molecular weight of approximately 195.57 g/mol. It is slightly soluble in water and more soluble in organic solvents. Chemically, it is an electron-withdrawing compound, making it less reactive towards basic reagents. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

How is (5-Chloro-2-pyrazinyl)methanol (CAS: 72788-94-4) typically synthesized?

(5-Chloro-2-pyrazinyl)methanol can be synthesized through the reaction of 2-chloropyrazine with methanol in the presence of a base such as potassium hydroxide. The reaction is typically conducted in an inert atmosphere to prevent side reactions. The yield can be improved by using appropriate reaction conditions and catalysts.

What industries use (5-Chloro-2-pyrazinyl)methanol (CAS: 72788-94-4)?

(5-Chloro-2-pyrazinyl)methanol is used in various industries including pharmaceuticals for the synthesis of certain drugs, as a precursor in polymer production, and in the development of sensors and semiconductors. Its specific applications depend on its functional groups and reactivity.

What precautions should be taken when handling (5-Chloro-2-pyrazinyl)methanol (CAS: 72788-94-4)?

When handling (5-Chloro-2-pyrazinyl)methanol, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood. Store the compound in a cool, dry place away from direct sunlight and flammable materials. In case of a spill, neutralize the spill with an appropriate reagent and dispose of the material according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed handling instructions.