5-Methoxy-6-nitro-1H-indazole

Basic Information

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CAS Number

724767-15-1

Molecular Formula

C8H7N3O3

Molecular Weight

193.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

SMILES

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COC1=C(C=C2C(=C1)C=NN2)[N+](=O)[O-]

InChI

InChI=1S/C8H7N3O3/c1-14-8-2-5-4-9-10-6(5)3-7(8)11(12)13/h2-4H,1H3,(H,9,10)

InChIKey

NGZRHTSGWGCDDC-UHFFFAOYSA-N

Complexity

230

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

CL3501
5-METHOXY-6-NITRO-1H-INDAZOLE
AKOS006308718
FT-0726722
1H-Indazole,5-methoxy-6-nitro-(9CI)
MFCD11110272
DTXSID00666847
724767-15-1
SY068086
CS-0042971
DS-9539
1H-Indazole,5-methoxy-6-nitro-
SCHEMBL22411805
SB12038
5-Methoxy-6-nitro-1H-indazole

MDL Number

MFCD11110272

FAQ

What are the physical and chemical properties of 5-Methoxy-6-nitro-1H-indazole (CAS: 724767-15-1)?

5-Methoxy-6-nitro-1H-indazole (CAS: 724767-15-1) is a crystalline solid with a molecular weight of approximately 223.12 g/mol. It is slightly soluble in water but highly soluble in organic solvents like ethanol and acetone. The compound shows moderate reactivity towards nucleophiles and can undergo substitution reactions. It has a melting point of about 225-227°C and is stable under normal laboratory conditions.

How is 5-Methoxy-6-nitro-1H-indazole (CAS: 724767-15-1) typically synthesized?

5-Methoxy-6-nitro-1H-indazole is typically synthesized through the nitration of 5-methoxy-1H-indazole followed by reduction. This involves the use of nitric acid and sulfuric acid as a nitrating mixture. The reduction step can be achieved using sodium borohydride or sodium cyanoborohydride to introduce the nitro group. The process typically yields 80-85% purity with high selectivity and good yield.

What industries use 5-Methoxy-6-nitro-1H-indazole (CAS: 724767-15-1)?

5-Methoxy-6-nitro-1H-indazole (CAS: 724767-15-1) has applications in the pharmaceutical industry for the synthesis of certain medicinal compounds. It is also used in the development of sensors for detecting various chemicals and in the semiconductor industry for specific applications in electronic devices. Its use in polymer chemistry is limited but it can be incorporated into certain polymer systems for enhanced properties.

What precautions should be taken when handling 5-Methoxy-6-nitro-1H-indazole (CAS: 724767-15-1)?

When handling 5-Methoxy-6-nitro-1H-indazole (CAS: 724767-15-1), it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from incompatible materials. Handling should be done in a well-ventilated area or a fume hood to minimize inhalation risk. In case of a spill, ensure proper cleanup procedures are followed, and the Material Safety Data Sheet (MSDS) should be consulted for specific instructions.