5-Methoxy-6-nitro-1H-indazole(CAS: 724767-15-1)

5-Methoxy-6-nitro-1H-indazole (CAS: 724767-15-1) is a crystalline solid with a molecular weight of approximately 223.12 g/mol. It is slightly soluble in water but highly soluble in organic solvents like ethanol and acetone. The compound shows moderate reactivity towards nucleophiles and can undergo substitution reactions. It has a melting point of about 225-227°C and is stable under normal laboratory conditions.

5-Methoxy-6-nitro-1H-indazole is typically synthesized through the nitration of 5-methoxy-1H-indazole followed by reduction. This involves the use of nitric acid and sulfuric acid as a nitrating mixture. The reduction step can be achieved using sodium borohydride or sodium cyanoborohydride to introduce the nitro group. The process typically yields 80-85% purity with high selectivity and good yield.

5-Methoxy-6-nitro-1H-indazole (CAS: 724767-15-1) has applications in the pharmaceutical industry for the synthesis of certain medicinal compounds. It is also used in the development of sensors for detecting various chemicals and in the semiconductor industry for specific applications in electronic devices. Its use in polymer chemistry is limited but it can be incorporated into certain polymer systems for enhanced properties.

When handling 5-Methoxy-6-nitro-1H-indazole (CAS: 724767-15-1), it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from incompatible materials. Handling should be done in a well-ventilated area or a fume hood to minimize inhalation risk. In case of a spill, ensure proper cleanup procedures are followed, and the Material Safety Data Sheet (MSDS) should be consulted for specific instructions.