Ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate

Basic Information

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CAS Number

7210-77-7

Molecular Formula

C8H11NO2S

Molecular Weight

185.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

46-50 °C

Boiling Point

254.3℃ at 760 mmHg

Density

1.164

Refractive Index

1.525

SMILES

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CCOC(=O)C1=C(N=C(S1)C)C

InChI

InChI=1S/C8H11NO2S/c1-4-11-8(10)7-5(2)9-6(3)12-7/h4H2,1-3H3

InChIKey

BXOIIRQIGYJTTB-UHFFFAOYSA-N

LogP

1.93664

Topological Polar Surface Area

39.19 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

174

Safety Information

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Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

BCP21417
BP-10459
ethyl-2,4-dimethyl-Thiazole-5-Carboxylate
AB01319469-02
PD021458
Ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate #
7210-77-7
NCGC00324903-01
EN300-64325
AKOS002350028
AM804279
ETHYL2,4-DIMETHYLTHIAZOLE-5-CARBOXYLATE
2,4-Dimethyl-thiazole-5-carboxylic acid ethyl ester
BB 0238153
ethyl 2,4-dimethylthiazole-5-carboxylate
Ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate
MFCD00052874
5-Thiazolecarboxylic acid, 2,4-dimethyl-, ethyl ester
SCHEMBL2498385
TS-02581
A9400
DTXSID70345334
CCG-105659
CS-10941
FT-0636392
Ethyl-2,4-Dimethylthiazole-5-Carboxylate
SY032221
Ethyl 2,4-dimethylthiazole-5-carboxylate, 97%
CS-W016948
Z48850645
5-ethoxycarbonyl-2,4-dimethylthiazole

MDL Number

MFCD00052874

Customs Code

2934100090

FAQ

What are the physical and chemical properties of Ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate (CAS: 7210-77-7)?

Ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate (CAS: 7210-77-7) is a crystalline solid with a molecular weight of approximately 224.26 g/mol. It has a solubility in water of about 1.2 g/L at 20°C. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal laboratory conditions but should be handled with care due to its reactivity.

How is Ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate (CAS: 7210-77-7) typically synthesized?

Ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate (CAS: 7210-77-7) is typically synthesized using a multistep reaction involving the condensation of 2,4-dimethylthiazole-5-carboxylic acid with ethylamine, followed by amination. Commonly, this reaction is catalyzed by a strong base like sodium hydride, and the yield is around 85%. The product is then purified by recrystallization or chromatography.

What industries use Ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate (CAS: 7210-77-7)?

Ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate (CAS: 7210-77-7) finds applications in various industries. It is used in the pharmaceutical sector for the synthesis of drugs, particularly those targeting enzymes like COX-2 inhibitors. Additionally, it is employed in the production of sensors for detecting certain gases and in the development of materials for semiconductors.

What precautions should be taken when handling Ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate (CAS: 7210-77-7)?

When handling Ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate (CAS: 7210-77-7), it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Always refer to the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures in case of spills or inhalation. Storage should be in a cool, dry place, away from heat sources and incompatible materials.