Ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate(CAS: 7210-77-7)

Ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate (CAS: 7210-77-7) is a crystalline solid with a molecular weight of approximately 224.26 g/mol. It has a solubility in water of about 1.2 g/L at 20°C. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal laboratory conditions but should be handled with care due to its reactivity.

Ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate (CAS: 7210-77-7) is typically synthesized using a multistep reaction involving the condensation of 2,4-dimethylthiazole-5-carboxylic acid with ethylamine, followed by amination. Commonly, this reaction is catalyzed by a strong base like sodium hydride, and the yield is around 85%. The product is then purified by recrystallization or chromatography.

Ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate (CAS: 7210-77-7) finds applications in various industries. It is used in the pharmaceutical sector for the synthesis of drugs, particularly those targeting enzymes like COX-2 inhibitors. Additionally, it is employed in the production of sensors for detecting certain gases and in the development of materials for semiconductors.

When handling Ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate (CAS: 7210-77-7), it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Always refer to the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures in case of spills or inhalation. Storage should be in a cool, dry place, away from heat sources and incompatible materials.