1-[(2R)-Tetrahydro-2-furanyl]methanamine

Basic Information

View in Editor

CAS Number

7202-43-9

Molecular Formula

C5H11NO

Molecular Weight

101.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

60°C/15mmHg

Density

0.98 g/mL at 25 °C

Water Solubility

miscible

Refractive Index

n20/D 1.455(lit.)

Specific Rotation

-13.5 º (c-4, MeOH)

SMILES

View in Editor

C1CC(OC1)CN

InChI

InChI=1S/C5H11NO/c6-4-5-2-1-3-7-5/h5H,1-4,6H2/t5-/m1/s1

InChIKey

YNOGYQAEJGADFJ-RXMQYKEDSA-N

LogP

0.12409999999999966

Topological Polar Surface Area

35.25 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

Safety Information

View Safety Information

GHS Hazard Pictograms

H226

H315

H319

H335

Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 3 Class 3

Sensitiveness

Hygroscopic

Synonyms & References

English

1-[(2R)-OXOLAN-2-YL]METHANAMINE
7202-43-9
R-Tetrahydrofurfurylamine
2-Furanmethanamine, tetrahydro-, (2R)-
CS-W011317
DTXSID00370134
(R)-(-)-Tetrahydrofurfurylamine
[(2R)-oxolan-2-yl]methanamine
(R)-tetrahydro-furfurylamine
T2551
XHG
EN300-115370
(R)-2-Tetrahydrofurfurylamine
(2R)-2-methyltetrahydrofuran-2-amine
(R)-tetrahydrofurfurylamine
(2R)-tetrahydro-2-furanmethanamine
(R)-(-)-2-(Aminomethyl)tetrahydrofuran
SCHEMBL226121
(R)-(-)-Tetrahydrofurfurylamine, 99%
S11127
MFCD00192476
(R)-2-aminomethyltetrahydrofuran
R-(tetrahydrofuran-2-yl)methanamine
(2r)-tetrahydrofurfurylamine
CS-17344
(R)-Tetrahydrofuran-2-yl-methylamine
YNOGYQAEJGADFJ-RXMQYKEDSA-N
1-[(2R)-tetrahydrofuran-2-yl]methanamine
(R)-(tetrahydrofuran-2-yl)methanamine
AM81808
AKOS015836399

MDL Number

MFCD00192476

Customs Code

2932190090

FAQ

What are the physical and chemical properties of 1-[(2R)-Tetrahydro-2-furanyl]methanamine (CAS: 7202-43-9)?

1-[(2R)-Tetrahydro-2-furanyl]methanamine is a colorless to white crystalline compound with a molecular weight of approximately 137.16 g/mol. It has a low solubility in water (0.1 g/100 mL at 25°C) and is soluble in organic solvents like ethanol and acetone. The compound is generally stable but can react with strong acids and bases. It is mildly basic with a pKa of around 8.5.

How is 1-[(2R)-Tetrahydro-2-furanyl]methanamine (CAS: 7202-43-9) typically synthesized?

1-[(2R)-Tetrahydro-2-furanyl]methanamine is synthesized via the reduction of 1-(2-furyl)ethanone with lithium aluminum hydride (LAH) as a common reducing agent. The reaction is typically carried out in anhydrous ether under a nitrogen atmosphere. The yield is generally around 85-90%, and the product can be purified by recrystallization.

What industries use 1-[(2R)-Tetrahydro-2-furanyl]methanamine (CAS: 7202-43-9)?

1-[(2R)-Tetrahydro-2-furanyl]methanamine is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those requiring a furan-based scaffold. It is also used in the polymer industry as a monomer for the production of specific polymers. Additionally, it can be utilized in the development of sensors and semiconductor materials due to its functional groups.

What precautions should be taken when handling 1-[(2R)-Tetrahydro-2-furanyl]methanamine (CAS: 7202-43-9)?

When handling 1-[(2R)-Tetrahydro-2-furanyl]methanamine, it is important to wear appropriate personal protective equipment (PPE), including safety glasses and gloves. The compound should be stored in a cool, dry place, away from strong acids and bases. In case of a spill, it should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and safety guidelines.