1-[(2R)-Tetrahydro-2-furanyl]methanamine(CAS: 7202-43-9)

1-[(2R)-Tetrahydro-2-furanyl]methanamine is a colorless to white crystalline compound with a molecular weight of approximately 137.16 g/mol. It has a low solubility in water (0.1 g/100 mL at 25°C) and is soluble in organic solvents like ethanol and acetone. The compound is generally stable but can react with strong acids and bases. It is mildly basic with a pKa of around 8.5.

1-[(2R)-Tetrahydro-2-furanyl]methanamine is synthesized via the reduction of 1-(2-furyl)ethanone with lithium aluminum hydride (LAH) as a common reducing agent. The reaction is typically carried out in anhydrous ether under a nitrogen atmosphere. The yield is generally around 85-90%, and the product can be purified by recrystallization.

1-[(2R)-Tetrahydro-2-furanyl]methanamine is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those requiring a furan-based scaffold. It is also used in the polymer industry as a monomer for the production of specific polymers. Additionally, it can be utilized in the development of sensors and semiconductor materials due to its functional groups.

When handling 1-[(2R)-Tetrahydro-2-furanyl]methanamine, it is important to wear appropriate personal protective equipment (PPE), including safety glasses and gloves. The compound should be stored in a cool, dry place, away from strong acids and bases. In case of a spill, it should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and safety guidelines.