3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Basic Information

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CAS Number

719268-92-5

Molecular Formula

C11H15BFNO2

Molecular Weight

223.06 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

55.0 to 59.0 deg-C

Boiling Point

294.487°C at 760 mmHg

Density

1.1

Flash Point

131.901°C

Refractive Index

1.477

SMILES

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B1(OC(C(O1)(C)C)(C)C)C2=CC(=CN=C2)F

InChI

InChI=1S/C11H15BFNO2/c1-10(2)11(3,4)16-12(15-10)8-5-9(13)7-14-6-8/h5-7H,1-4H3

InChIKey

VFMTUTYBMBTIGA-UHFFFAOYSA-N

LogP

1.5198999999999998

Topological Polar Surface Area

31.35 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

257

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, AldrichCPR
5-Fluoropyridine-3-boronic acid, pinacol ester
3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
3-Fluoropyridine-5-boronic acid pinacol ester
3-Fluoropyridine-5-boronic acid pinacol eater
AKOS015842141
AB42551
Z1336745108
(5-FLUOROPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER
SCHEMBL975905
MFCD07780754
SY025633
F1026
A25352
3-Fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine
J-512509
CS-0109834
719268-92-5
DTXSID50585993
3-Fluoropyridine-5-boronic acid, pinacol ester
3-Fluoro-5-(4455-tetramethyl-132-dioxaborolan-2-yl)pyridine
FT-0685800
AC-33452
DS-14891
5-Fluoro-3-pyridylboronic Acid Pinacol Ester
VFMTUTYBMBTIGA-UHFFFAOYSA-N
3-fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
AM20061465
2-(5-Fluoro-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
3-Fluoro-5-(4 pound not4 pound not5 pound not5-tetramethyl-1 pound not3 pound not2-dioxaborolan-2-yl)pyridine
EN300-160485

MDL Number

MFCD07780754

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS: 719268-92-5)?

3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a crystalline solid with a molecular weight of approximately 312.21 g/mol. It is sparingly soluble in water but soluble in organic solvents like DMSO and DMF. Chemically, it is stable under normal conditions but reactive towards strong bases and reducing agents. It exhibits good solubility in various solvents, making it useful in synthesis and catalytic reactions.

How is 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS: 719268-92-5) typically synthesized?

3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is typically synthesized via a coupling reaction starting from 3-fluoropyridine and 1,3,2-dioxaborinane in the presence of a palladium catalyst, such as Pd(PPh3)2Cl2, with a base like cesium carbonate. This process provides high yield and good selectivity, making it a reliable method for its synthesis.

What industries use 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS: 719268-92-5)?

3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine finds applications in pharmaceuticals, where it serves as a valuable building block in the synthesis of complex molecules. It is also used in the polymer industry for the development of advanced materials, and in electronics for the production of semiconductors and sensors. Its versatile chemical functionality makes it a useful compound in various research and industrial sectors.

What precautions should be taken when handling 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS: 719268-92-5)?

When handling 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, it is important to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be contained and cleaned up using appropriate absorbent materials, followed by thorough disposal according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.