1-(4-Piperidinyl)methanamine

Basic Information

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CAS Number

7144-05-0

Molecular Formula

C6H14N2

Molecular Weight

114.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

25 °C

Boiling Point

200 °C

Density

0.9151 (rough estimate)

Refractive Index

n20/D 1.49(lit.)

SMILES

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C1CNCCC1CN

InChI

InChI=1S/C6H14N2/c7-5-6-1-3-8-4-2-6/h6,8H,1-5,7H2

InChIKey

LTEKQAPRXFBRNN-UHFFFAOYSA-N

LogP

-0.05530000000000013

Topological Polar Surface Area

38.05 Å²

Hydrogen Bond Donor/Acceptor

3 / 2

Complexity

57.5

Safety Information

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GHS Hazard Pictograms

H314

Hazard Statement

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Air Sensitive

Synonyms & References

English

BP-13005
FT-0617581
1-piperidin-4-ylmethanamine
1-(piperid-4-yl)methylamine
69F547MD7G
TS-01585
4-(Aminomethyl)piperidine
piperidin-4-ylmethanamine
4-(aminomethyl)-piperidine
F2191-0281
AMY3390
LTEKQAPRXFBRNN-UHFFFAOYSA-
W-111727
STR05635
4-AMP
4-[Aminomethyl]piperidine
A9351
NSC62826
4-Piperidinylmethanamine #
7144-05-0
piperidin-4-ylmethylamine
NS00037205
NSC 62826
4-Aminomethylpiperidine
DTXSID8064569
PMID28454500-Compound-94
1-(piperidin-4-yl)methanamine
(piperidin-4-ylmethyl)amine
Piperidine, 4-(aminomethyl)-
C-piperidin-4-yl-methylamine
EINECS 230-446-3

MDL Number

MFCD00006007

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 1-(4-Piperidinyl)methanamine (CAS: 7144-05-0)?

1-(4-Piperidinyl)methanamine has a crystalline form, a molecular weight of approximately 161.26 g/mol, and is slightly soluble in water. It is reactive towards acidic and basic conditions. The compound has moderate solubility in organic solvents like ethanol and acetone. It is used in medicinal chemistry and as an intermediate in organic synthesis.

How is 1-(4-Piperidinyl)methanamine (CAS: 7144-05-0) typically synthesized?

1-(4-Piperidinyl)methanamine can be synthesized through a multi-step process involving amidation of 4-piperidone with methylamine. The reaction proceeds under basic conditions, and the use of a catalyst like triethylamine can enhance yield and selectivity. The final product is purified by recrystallization from a suitable solvent.

What industries use 1-(4-Piperidinyl)methanamine (CAS: 7144-05-0)?

1-(4-Piperidinyl)methanamine is primarily used in the pharmaceutical industry due to its biological activity. It is also utilized in the synthesis of certain drugs and as an intermediate in polymer chemistry. This compound has potential applications in medicinal chemistry and sensor technology.

What precautions should be taken when handling 1-(4-Piperidinyl)methanamine (CAS: 7144-05-0)?

When handling 1-(4-Piperidinyl)methanamine, wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Store the compound in a dry, cool place away from direct sunlight and flammable materials. Always consult the safety data sheet (SDS) for specific handling and disposal guidelines.