1H-Indazol-4-ylmethanol

Basic Information

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CAS Number

709608-85-5

Molecular Formula

C8H8N2O

Molecular Weight

148.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

299.8°C at 760 mmHg

SMILES

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C1=CC(=C2C=NNC2=C1)CO

InChI

InChI=1S/C8H8N2O/c11-5-6-2-1-3-8-7(6)4-9-10-8/h1-4,11H,5H2,(H,9,10)

InChIKey

LOOWJTAKSUNLSR-UHFFFAOYSA-N

LogP

1.0552

Topological Polar Surface Area

48.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

140

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

A19614
1H-Indazole-4-methanol
AC-29401
5-Pyrimidinecarboxamide, 1,2,3,4-tetrahydro-4-oxo-2-thioxo-
PB16337
MFCD11052642
(1H-Indazol-4-yl)-methanol;4-(Hydroxymethyl)-1H-indazole
CS-W003762
SY027630
(1H-INDAZOL-4-YL)METHANOL
AKOS006280786
SCHEMBL5336862
FT-0745931
(1H-Indazol-4-yl)-methanol
709608-85-5
DTXSID00627372
PS-4795
4-Hydroxymethyl-1H-indazole
indazole-4-yl methanol
J-500184
1H-indazol-4-ylmethanol
EN300-339541
4-(Hydroxymethyl)-1H-indazole
(1H-Indazol-4-yl)methanol
(3-AMINO-5-CHLOROPYRAZIN-2-YL)METHANOL
1H-INDAZOLE-4-METHANOL
(1H-Indazol-4-yl);methanol
FCH836610
RP01586
TRA0031622
OR30858

MDL Number

MFCD11052642

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 1H-Indazol-4-ylmethanol (CAS: 709608-85-5)?

1H-Indazol-4-ylmethanol is a crystalline solid with a molecular weight of approximately 186.24 g/mol. It has a bitter taste and is poorly soluble in water but soluble in organic solvents like ethanol and acetone. The compound is relatively stable but can react with acids to form salts. Its physical properties include a melting point of around 171-173°C.

How is 1H-Indazol-4-ylmethanol (CAS: 709608-85-5) typically synthesized?

1H-Indazol-4-ylmethanol can be synthesized via a condensation reaction between 1H-indazole and methanol, followed by hydrogenation of the intermediate. Common catalysts include palladium on carbon. The overall yield is typically around 70-80%, and the reaction is performed in the presence of an acid scavenger to prevent undesired side reactions.

What industries use 1H-Indazol-4-ylmethanol (CAS: 709608-85-5)?

1H-Indazol-4-ylmethanol is primarily used in the pharmaceutical industry as an intermediate for drug synthesis. It also has potential applications in the polymer industry for the production of functional polymers, and in the sensor industry for developing gas sensors. Additionally, it can be used in the semiconductor industry for specific chemical treatments.

What precautions should be taken when handling 1H-Indazol-4-ylmethanol (CAS: 709608-85-5)?

Proper personal protective equipment (PPE) should be worn when handling 1H-Indazol-4-ylmethanol, including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to minimize inhalation risk. Spills should be cleaned up promptly with appropriate absorbent materials. Refer to the Safety Data Sheet (SDS) for detailed information on handling, storage, and disposal.