1H-Indazol-4-ylmethanol(CAS: 709608-85-5)

1H-Indazol-4-ylmethanol is a crystalline solid with a molecular weight of approximately 186.24 g/mol. It has a bitter taste and is poorly soluble in water but soluble in organic solvents like ethanol and acetone. The compound is relatively stable but can react with acids to form salts. Its physical properties include a melting point of around 171-173°C.

1H-Indazol-4-ylmethanol can be synthesized via a condensation reaction between 1H-indazole and methanol, followed by hydrogenation of the intermediate. Common catalysts include palladium on carbon. The overall yield is typically around 70-80%, and the reaction is performed in the presence of an acid scavenger to prevent undesired side reactions.

1H-Indazol-4-ylmethanol is primarily used in the pharmaceutical industry as an intermediate for drug synthesis. It also has potential applications in the polymer industry for the production of functional polymers, and in the sensor industry for developing gas sensors. Additionally, it can be used in the semiconductor industry for specific chemical treatments.

Proper personal protective equipment (PPE) should be worn when handling 1H-Indazol-4-ylmethanol, including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to minimize inhalation risk. Spills should be cleaned up promptly with appropriate absorbent materials. Refer to the Safety Data Sheet (SDS) for detailed information on handling, storage, and disposal.