3'-Deoxyuridine

Basic Information

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CAS Number

7057-27-4

Molecular Formula

C9H12N2O5

Molecular Weight

228.2 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

174-176 ºC

Density

1.533±0.06 g/cm3 (20 ºC 760 Torr),

Water Solubility

Soluble in DMSO, methanol, or water. Also soluble in dichloromethane /n

SMILES

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C1C(OC(C1O)N2C=CC(=O)NC2=O)CO

InChI

InChI=1S/C9H12N2O5/c12-4-5-3-6(13)8(16-5)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1

InChIKey

QOXJRLADYHZRGC-SHYZEUOFSA-N

LogP

-1.8226999999999998

Topological Polar Surface Area

104.55000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

343

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

MFCD00079153
Uridine, 3'-deoxy-
1-[(2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione
3'-Deoxyuridine
CS-W012998
A855655
QOXJRLADYHZRGC-SHYZEUOFSA-N
SCHEMBL1145390
AC-32254
F11002
CHEMBL1169399
3'-Deoxy Uridine
1-[(2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
3??-Deoxyuridine
1-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
PD164979
DTXSID20220849
HY-W012282
AKOS025287088
1-[(2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
7057-27-4
AS-81963
3 inverted exclamation marka-Deoxyuridine
3’-Deoxy Uridine
3’-DEOXY URIDINE,WHITE TO OFF-WHITE SOLID
3-DEOXYURIDINE
3'-deoxy-uridine
3'-Desoxy-uridin
Uridine,3'-deoxy
3′-Deoxyuridine

MDL Number

MFCD00079153

Customs Code

29389090

FAQ

What are the physical and chemical properties of 3'-Deoxyuridine (CAS: 7057-27-4)?

3'-Deoxyuridine is a white crystalline solid with a molecular weight of approximately 238.22 g/mol. It is poorly soluble in water but soluble in organic solvents like methanol and ethanol. Chemically, it is relatively stable but can undergo hydrolysis under acidic or basic conditions. It does not generally react with common reagents unless under specific conditions.

How is 3'-Deoxyuridine (CAS: 7057-27-4) typically synthesized?

3'-Deoxyuridine is typically synthesized through a multi-step process involving the protection of uracil, followed by its conversion to 3'-deoxyuridine monophosphate and subsequent conversion to 3'-deoxyuridine. Common catalysts include phosphorylating agents, and the yield can be enhanced by optimizing reaction conditions and using high-purity starting materials.

What industries use 3'-Deoxyuridine (CAS: 7057-27-4)?

3'-Deoxyuridine is primarily used in the pharmaceutical industry for the development of antiviral drugs. It is also used in research for studying DNA replication and repair mechanisms. Additionally, it has applications in the development of nucleic acid-based sensors and as a component in some semiconductors.

What precautions should be taken when handling 3'-Deoxyuridine (CAS: 7057-27-4)?

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn when handling 3'-Deoxyuridine. Work should be carried out in a well-ventilated fume hood to minimize inhalation risk. Spills should be cleaned up immediately using appropriate absorbent materials and the area decontaminated. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.