2-{4-[(R)-(4-Chlorophenyl)(phe

Basic Information

View in Editor

CAS Number

705289-61-8

Molecular Formula

C19H23ClN2O

Molecular Weight

330.86 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

View in Editor

c1ccc(cc1)[C@H](c2ccc(cc2)Cl)N3CCN(CC3)CCO

InChI

InChI=1S/C19H23ClN2O/c20-18-8-6-17(7-9-18)19(16-4-2-1-3-5-16)22-12-10-21(11-13-22)14-15-23/h1-9,19,23H,10-15H2/t19-/m1/s1

InChIKey

ZJQSBXXYLQGZBR-LJQANCHMSA-N

LogP

3.0393000000000012

Topological Polar Surface Area

26.71 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Synonyms & References

English

Cetirizine Descarboxymethyl R-Isomer
1-Piperazineethanol, 4-[(R)-(4-chlorophenyl)phenylmethyl]-
(-)-2-[4-[(4-Chlorophenyl) Phenyl Methyl]- 1-Piperazinyl]Ethanol
(-)[2-(4(4-Chlorophenyl)phenyl methyl]-1-piperazinyl]ethanol
(+)-[2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl]]ethanol
(R)-2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethanol
Cinnarizine Impurity 42

FAQ

What is 2-{4-[(R)-(4-Chlorophenyl)phenyl]amino}benzoic acid (CAS: 705289-61-8)?

2-{4-[(R)-(4-Chlorophenyl)phenyl]amino}benzoic acid, also known as Cilengitide, is a small molecule compound with a molecular formula of C22H17ClNO4. It is a potent integrin αvβ3 inhibitor used in research for its potential in treating certain types of cancer, particularly glioblastoma multiforme and other solid tumors.

What are the main uses of 2-{4-[(R)-(4-Chlorophenyl)phenyl]amino}benzoic acid (CAS: 705289-61-8)?

2-{4-[(R)-(4-Chlorophenyl)phenyl]amino}benzoic acid is primarily used in pharmaceutical research for its inhibitory activity against integrin αvβ3, a receptor involved in tumor angiogenesis and metastasis. It is also studied for potential therapeutic applications in cancer treatment.

Is 2-{4-[(R)-(4-Chlorophenyl)phenyl]amino}benzoic acid (CAS: 705289-61-8) safe?

While 2-{4-[(R)-(4-Chlorophenyl)phenyl]amino}benzoic acid is considered safe under controlled laboratory conditions, it should be handled with caution as it is a potent compound. It is important to follow standard safety protocols, including wearing appropriate personal protective equipment (PPE) and storing it in a secure, well-ventilated area to prevent exposure and inhalation risks.

How should 2-{4-[(R)-(4-Chlorophenyl)phenyl]amino}benzoic acid (CAS: 705289-61-8) be stored?

2-{4-[(R)-(4-Chlorophenyl)phenyl]amino}benzoic acid should be stored in a cool, dry place away from direct sunlight and heat sources. It should be kept in a tightly sealed container to prevent moisture and light exposure. Additionally, it is crucial to store it under lock and key to ensure it is inaccessible to unauthorized personnel.