1-Ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | CAS No. 70458-92-3
1-Ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
Basic Information
CAS Number
70458-92-3
Molecular Formula
C17H20FN3O3
Molecular Weight
333.36 g/mol
AD
Chemical Classification
Basic Physical Properties
Melting Point
270-272° (dec)
Safety Information
View Safety InformationToxicity
LD50 in mice (mg/kg): 225 i.v., 1000 orally; in rats (g/kg): 1.5 i.p., 2.5 orally (Goueffon)
Synonyms & References
English
- MLS006011797
- EU 5306
- 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methyl-1-piperazinyl)-3-quinolinecarboxylic acid
- AKOS000280245
- 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methylpiperazinyl)quinoline-3-carboxylic Acid
- HY-B0147
- BAS 00463355
- BCP20511
- Pefloxacin (USAN/INN)
- F5577-0091
- PFLX
- EINECS 274-611-8
- cid_119525
- EU-5306
- CHEMBL267648
- AM-725
- HMS1613E05
- Pefloxacin, Antibiotic for Culture Media Use Only
- VS-01991
- Pefloxacinium mesylate
- 70458-92-3
- AB00600922_16
- SR-01000356843-1
- HMS3713G04
- EN300-18563416
- CCRIS 8210
- 1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CARBOXYLICACID
- 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-
- DTXSID3048493
- NS00002648
- 3-Quinolinecarboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-
MDL Number
MFCD00865015
FAQ
What are the physical and chemical properties of 1-Ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (CAS: 70458-92-3)?
1-Ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid is a crystalline compound with a molecular weight of approximately 328.31 g/mol. It has a low solubility in water (0.012 g/100 mL at 25°C) but is soluble in organic solvents like DMSO and acetonitrile. The compound exhibits good stability under normal conditions but reacts with strong bases and acids. It can be identified by its UV/Vis spectrum and NMR spectroscopy.
How is 1-Ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (CAS: 70458-92-3) typically synthesized?
The compound is typically synthesized via a multi-step process involving the reaction of a fluoroquinoline with a piperazine derivative. Key steps include the formation of an intermediate quinoline ring and subsequent reactions to introduce the ethyl and methyl groups. The synthesis often employs catalytic hydrogenation and selective alkylation reactions. The overall yield is moderate, around 50-60%, and the process requires careful control of reaction conditions to achieve high purity.
What industries use 1-Ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (CAS: 70458-92-3)?
1-Ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It finds applications in the development of novel therapeutic agents, particularly in areas such as neurology and immunology. Additionally, it has potential uses in polymer science and as a component in sensor technology due to its unique chemical properties.
What precautions should be taken when handling 1-Ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (CAS: 70458-92-3)?
When handling 1-Ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated fume hood to minimize exposure. Spills should be cleaned up immediately with appropriate absorbent materials. Refer to the safety data sheet (SDS) for specific handling and storage instructions to ensure compliance with laboratory safety standards.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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