Glycyl-L-proline

Basic Information

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CAS Number

704-15-4

Molecular Formula

C7H12N2O3

Molecular Weight

172.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

185 ºC

Boiling Point

411.3°C at 760 mmHg

Density

1.356±0.06 g/cm3 (20 ºC 760 Torr),

Water Solubility

very faint turbidity

Refractive Index

-114 ° (C=4, H2O)

SMILES

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C1CC(N(C1)C(=O)CN)C(=O)O

InChI

InChI=1S/C7H12N2O3/c8-4-6(10)9-3-1-2-5(9)7(11)12/h5H,1-4,8H2,(H,11,12)/t5-/m0/s1

InChIKey

KZNQNBZMBZJQJO-YFKPBYRVSA-N

LogP

-0.9792999999999998

Topological Polar Surface Area

83.63000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

205

Safety Information

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Hazard Statement

Sensitiveness

Sensitive to humidity

Synonyms & References

English

Gly-L-Pro
L-Proline, 1-glycyl-
704-15-4
AKOS015855091
N-glycylproline
AKOS010366353
J-521416
GP-OH
CHEMBL80548
1-glycyl-L-Proline
NSC 97929
1-(Aminoacetyl)proline
HY-W016887
(2S)-1-(aminoacetyl)pyrrolidine-2-carboxylic acid
(S)-1-(2-Amino-acetyl)-pyrrolidine-2-carboxylic acid
NSC-97929
EINECS 211-880-2
DTXSID701016976
s6133
Proline, 1-glycyl-, L-
Glycyl proline
(2S)-1-(2-aminoacetyl)pyrrolidine-2-carboxylic acid
gly-pro
DS-16203
KZNQNBZMBZJQJO-YFKPBYRVSA-N
1-GLYCYLPROLINE, L-
Glycyl-L-proline
1-(2-Amino-acetyl)-pyrrolidine-2-carboxylic acid
BJZ69WB3VD
H-Gly-Pro-OH
N-Glycyl-L-proline

MDL Number

MFCD00020840

Customs Code

2933990090

FAQ

What are the physical and chemical properties of Glycyl-L-proline (CAS: 704-15-4)?

Glycyl-L-proline (CAS: 704-15-4) is a crystalline compound with a molecular weight of approximately 187.23 g/mol. It is slightly soluble in water and has a pKa of 2.7. This compound exhibits moderate reactivity, particularly in amide bond formation. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

How is Glycyl-L-proline (CAS: 704-15-4) typically synthesized?

Glycyl-L-proline (CAS: 704-15-4) can be synthesized via the coupling of glycine and L-proline. Commonly, this is achieved using chemical coupling reagents such as 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS). The yield can reach up to 75%, with high selectivity for the desired product.

What industries use Glycyl-L-proline (CAS: 704-15-4)?

Glycyl-L-proline (CAS: 704-15-4) is used in various industries. In pharmaceuticals, it serves as a building block for peptide synthesis. It is also utilized in the production of polymers, where it acts as a monomer. Additionally, it finds applications in sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling Glycyl-L-proline (CAS: 704-15-4)?

When handling Glycyl-L-proline (CAS: 704-15-4), it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood. In case of spillage, avoid contact with skin and eyes, and clean up using appropriate chemical spill kits. Always consult the Safety Data Sheet (SDS) for detailed handling instructions.