7-[2-(4-Morpholinyl)ethoxy]-4-[2-(2-pyridinyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline | CAS No. 700874-71-1

7-[2-(4-Morpholinyl)ethoxy]-4-[2-(2-pyridinyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline

Basic Information

CAS Number

700874-71-1

Molecular Formula

C26H27N5O2

Molecular Weight

441.54 g/mol

AD

Basic Physical Properties

Density

1.34

C1CC2=C(C(=NN2C1)C3=CC=CC=N3)C4=C5C=CC(=CC5=NC=C4)OCCN6CCOCC6

InChI

InChI=1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2

InChIKey

IHLVSLOZUHKNMQ-UHFFFAOYSA-N

LogP

3.8175000000000034

Topological Polar Surface Area

65.3 Ų

Hydrogen Bond Donor/Acceptor

0 / 7

Complexity

632

Synonyms & References

English

  • BDBM21509
  • FT-0698866
  • Quinoline, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]-
  • LY 2109761
  • s2704
  • HMS3674E17
  • LY-2109761
  • BCP9000868
  • SCHEMBL3737735
  • Q27082613
  • 4-(5,6-Dihydro-2-(2-pyridinyl)-4H-pyrrolo(1,2-b)pyrazol-3-yl)-7-(2-(4-morpholinyl)ethoxy)quinoline
  • NSC765632
  • SB19481
  • AS-56101
  • AKOS022183732
  • LY2109761
  • CHEMBL260015
  • NCGC00242598-10
  • DTXSID30470111
  • 700874-71-1
  • IHLVSLOZUHKNMQ-UHFFFAOYSA-N
  • GTPL8075
  • AC-30289
  • SMR004702772
  • 4-[2-[4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl]oxyethyl]morpholine
  • 4-(2-((4-(2-(Pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl)oxy)ethyl)morpholine
  • LY2109761,CAS:700874-71-1
  • J-514249
  • BCP02824
  • 4-[5,6-Dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]quinoline
  • NCGC00242598-03

MDL Number

MFCD12923354

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 7-[2-(4-Morpholinyl)ethoxy]-4-[2-(2-pyridinyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline (CAS: 700874-71-1)?

The compound has a solid crystalline form with a molecular weight of approximately 542.73 g/mol. It is slightly soluble in organic solvents like methanol and acetonitrile. Chemically, it is stable in neutral conditions but can be sensitive to strong acids and bases. It shows moderate reactivity towards electrophilic aromatic substitution and nucleophilic addition reactions.

How is 7-[2-(4-Morpholinyl)ethoxy]-4-[2-(2-pyridinyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline (CAS: 700874-71-1) typically synthesized?

It is synthesized through a multi-step process involving the reaction of 4-quinolinecarboxaldehyde with 2-(2-pyridinyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole followed by a coupling reaction with 2-(4-morpholinyl)ethanol. The synthesis involves the use of catalysts such as palladium(II) acetate and triphenylphosphine, and the process typically yields 70-80% of the desired product.

What industries use 7-[2-(4-Morpholinyl)ethoxy]-4-[2-(2-pyridinyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline (CAS: 700874-71-1)?

This compound is primarily used in the pharmaceutical industry for the development of new drugs due to its biological activity. It also has potential applications in the production of polymers with specific properties and as a precursor in the synthesis of other complex organic molecules.

What precautions should be taken when handling 7-[2-(4-Morpholinyl)ethoxy]-4-[2-(2-pyridinyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline (CAS: 700874-71-1)?

When handling this compound, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation. Spills should be cleaned up immediately with caution, following safety data sheet (SDS) guidelines. Always consult the SDS for the most up-to-date handling and disposal information.

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