4-fluoropyridine

Basic Information

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CAS Number

694-52-0

Molecular Formula

C5H4FN

Molecular Weight

97.09 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

104-105℃

Refractive Index

1.473

SMILES

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C1=CN=CC=C1F

InChI

InChI=1S/C5H4FN/c6-5-1-3-7-4-2-5/h1-4H

InChIKey

TTYVECQWCUJXCS-UHFFFAOYSA-N

LogP

1.2207000000000001

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

Safety Information

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Hazard Statement

Synonyms & References

English

EN300-94215
4-Fluoropyridine
AKOS005145581
694-52-0
InChI=1/C5H4FN/c6-5-1-3-7-4-2-5/h1-4
DTXSID50219524
4-F-pyridine
4-fluoro-pyridine
FT-0632824
J-515423
AM81307
F19691
MFCD04039315
A9187
AC-452
Pyridine, 4-fluoro-
TTYVECQWCUJXCS-UHFFFAOYSA-N
4-fluoropyridine
4-Fluoropyrdine
4-Fluoro-pyridine
4-Fluoropyridin
4-FLUOROPYRIDINE HCL
4-Fluor-pyridin
P-FLUOROPYRIDINE
Pyridine,4-fluoro

MDL Number

MFCD04039315

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 4-fluoropyridine (CAS: 694-52-0)?

4-Fluoropyridine (CAS: 694-52-0) is a crystalline solid with a molecular weight of 117.02 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can react with strong bases and reductants. It is a key intermediate in the synthesis of various pharmaceuticals and materials.

How is 4-fluoropyridine (CAS: 694-52-0) typically synthesized?

4-Fluoropyridine (CAS: 694-52-0) is often synthesized via the nitration of pyridine followed by reduction of the nitrated product. Alternatively, it can be prepared by chlorination of pyridine and subsequent reduction. The synthesis typically requires the use of concentrated sulfuric acid as a catalyst and involves careful control of reaction conditions to achieve high selectivity and yield.

What industries use 4-fluoropyridine (CAS: 694-52-0)?

4-Fluoropyridine (CAS: 694-52-0) is widely used in the pharmaceutical industry for the synthesis of antiviral and antiparasitic drugs. It also finds applications in the production of electronic materials, specifically in the development of organic light-emitting diodes (OLEDs) and organic semiconductors. Additionally, it is used in the production of certain dyes and polymers.

What precautions should be taken when handling 4-fluoropyridine (CAS: 694-52-0)?

When handling 4-fluoropyridine (CAS: 694-52-0), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of fumes. Spills should be cleaned up using appropriate materials and procedures as outlined in the safety data sheet (SDS). Always refer to the SDS for detailed safety information and guidelines.