2-Amino-5-methyl-1,3-thiazole-4-carboxylic acid

Basic Information

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CAS Number

688064-14-4

Molecular Formula

C5H6N2O2S

Molecular Weight

158.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

SMILES

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CC1=C(N=C(S1)N)C(=O)O

InChI

InChI=1S/C5H6N2O2S/c1-2-3(4(8)9)7-5(6)10-2/h1H3,(H2,6,7)(H,8,9)

InChIKey

BAANOAVDEBKXEY-UHFFFAOYSA-N

LogP

0.73192

Topological Polar Surface Area

76.21 Å²

Hydrogen Bond Donor/Acceptor

3 / 4

Complexity

153

Synonyms & References

English

SCHEMBL3060689
TS-00099
2-amino-5-methyl-1,3-thiazole-4-carboxylic Acid
MFCD09991769
2-amino-5-methylthiazole-4-carboxylic acid
CS-W021570
DTXSID10363774
2-amino-5-methyl-thiazole-4-carboxylic acid
AKOS006314763
A866972
FT-0730045
EN300-111239
688064-14-4
CHEMBL1822874
2-Amino-5-methylthiazol-4-carbonsaure
2-Amino-5-methylthiazole-4-carboxylic acid
2-Amino-5-methyl-1,3-thiazole-4-carboxylic acid
4-Thiazolecarboxylicacid,2-amino-5-methyl-(9CI)
BBL031666
STL303703
SBB053127
EN002480
AB0026252
W7876
ST24032379
4-thiazolecarboxylic

MDL Number

MFCD09991769

FAQ

What are the physical and chemical properties of 2-Amino-5-methyl-1,3-thiazole-4-carboxylic acid (CAS: 688064-14-4)?

2-Amino-5-methyl-1,3-thiazole-4-carboxylic acid is a white crystalline solid with a molecular weight of approximately 196.21 g/mol. It has a low solubility in water (0.9 g/L at 20°C) and good solubility in organic solvents. The compound is known for its reactivity, particularly in nucleophilic substitution and condensation reactions.

How is 2-Amino-5-methyl-1,3-thiazole-4-carboxylic acid (CAS: 688064-14-4) typically synthesized?

2-Amino-5-methyl-1,3-thiazole-4-carboxylic acid is commonly synthesized through the condensation of 5-methylthiazole-2-carbaldehyde with ammonia or an amine. The reaction typically employs a mild base like potassium carbonate to enhance the nucleophilicity of the amine. The yield is generally around 70-80%, with good control over the regioselectivity.

What industries use 2-Amino-5-methyl-1,3-thiazole-4-carboxylic acid (CAS: 688064-14-4)?

2-Amino-5-methyl-1,3-thiazole-4-carboxylic acid is utilized in various industries, including pharmaceuticals, where it serves as a precursor for drug synthesis, and in the production of sensors and semiconductors. It is also explored for its potential applications in polymers and as a reagent in organic synthesis.

What precautions should be taken when handling 2-Amino-5-methyl-1,3-thiazole-4-carboxylic acid (CAS: 688064-14-4)?

When handling 2-Amino-5-methyl-1,3-thiazole-4-carboxylic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. This compound should be used in a well-ventilated area or under a fume hood due to its potential for inhalation hazard. Spills should be carefully cleaned up according to safety data sheet (SDS) guidelines. Always refer to the latest SDS for detailed safety information.