2-Amino-5-methyl-1,3-thiazole-4-carboxylic acid(CAS: 688064-14-4)

2-Amino-5-methyl-1,3-thiazole-4-carboxylic acid is a white crystalline solid with a molecular weight of approximately 196.21 g/mol. It has a low solubility in water (0.9 g/L at 20°C) and good solubility in organic solvents. The compound is known for its reactivity, particularly in nucleophilic substitution and condensation reactions.

2-Amino-5-methyl-1,3-thiazole-4-carboxylic acid is commonly synthesized through the condensation of 5-methylthiazole-2-carbaldehyde with ammonia or an amine. The reaction typically employs a mild base like potassium carbonate to enhance the nucleophilicity of the amine. The yield is generally around 70-80%, with good control over the regioselectivity.

2-Amino-5-methyl-1,3-thiazole-4-carboxylic acid is utilized in various industries, including pharmaceuticals, where it serves as a precursor for drug synthesis, and in the production of sensors and semiconductors. It is also explored for its potential applications in polymers and as a reagent in organic synthesis.

When handling 2-Amino-5-methyl-1,3-thiazole-4-carboxylic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. This compound should be used in a well-ventilated area or under a fume hood due to its potential for inhalation hazard. Spills should be carefully cleaned up according to safety data sheet (SDS) guidelines. Always refer to the latest SDS for detailed safety information.