2-[(2R)-2-Piperidinyl]ethanol

Basic Information

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CAS Number

68419-38-5

Molecular Formula

C7H15NO

Molecular Weight

129.2 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

234.5°C at 760 mmHg

SMILES

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C1CCNC(C1)CCO

InChI

InChI=1S/C7H15NO/c9-6-4-7-3-1-2-5-8-7/h7-9H,1-6H2/t7-/m1/s1

InChIKey

PTHDBHDZSMGHKF-SSDOTTSWSA-N

LogP

0.5108999999999997

Topological Polar Surface Area

32.26 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

75.3

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

A915323
F30243
(R)-(+)-Piperidine-2-Ethanol
2-[(2R)-piperidin-2-yl]ethanol
68419-38-5
SCHEMBL891139
(R)-2-(piperidin-2-yl)ethan-1-ol
AKOS016842404
CS-0155252
(r)-piperidine-2-ethanol
(R)-2-(Piperidin-2-yl)ethanol
2-PIPERIDINEETHANOL, (2R)-
MFCD08461073
(R)-2-Piperidineethanol
AMY21750
AS-48306
2-piperidin-2-yl-ethanol
(2R)-2-Piperidineethanol
(R)-2-Piperidineetha
(-) piperidine-2-ethanol
(2R)-2-(2-methoxyethyl)piperidine
(R)-2-(2-Hydroxyethyl)piperidine hydrochloride
(R)-2-Piperidineethanol hydrochloride
(R)-homopipecolic alcohol
2-((2R)-piperidin-2-yl)ethanol
2-PIPERIDINEETHANOL,(2R)
(+)-2-Piperidineethanol
(R)-(+)piperidine-2-Ethanol
(R)-2-(2-Hydroxyethyl)piperidine
2-[(2R)-Piperidine-2-yl]ethanol
RW1049

MDL Number

MFCD08461073

FAQ

What are the physical and chemical properties of 2-[(2R)-2-Piperidinyl]ethanol (CAS: 68419-38-5)?

2-[(2R)-2-Piperidinyl]ethanol is a colorless liquid with a distinctive odor. Its molecular weight is approximately 149.26 g/mol. It is soluble in water and ethanol. Chemically, it is relatively stable but can undergo hydrolysis under basic conditions. It is a chiral molecule with a stereogenic center at the 2-position of the piperidine ring.

How is 2-[(2R)-2-Piperidinyl]ethanol (CAS: 68419-38-5) typically synthesized?

2-[(2R)-2-Piperidinyl]ethanol is typically synthesized through a multi-step process involving the protection of the hydroxyl group of 2-piperidineethanol, followed by selective reduction of the ketone to an alcohol. This often involves using reducing agents like sodium borohydride and specific chiral catalysts to achieve high enantiomeric excess. The overall yield is around 70-80%.

What industries use 2-[(2R)-2-Piperidinyl]ethanol (CAS: 68419-38-5)?

2-[(2R)-2-Piperidinyl]ethanol is used in the pharmaceutical industry as a chiral intermediate for the synthesis of various drugs. It is also utilized in the polymer industry as an additive to improve the properties of polymers. Additionally, it has applications in sensor technology and semiconductor manufacturing as a reagent.

What precautions should be taken when handling 2-[(2R)-2-Piperidinyl]ethanol (CAS: 68419-38-5)?

When handling 2-[(2R)-2-Piperidinyl]ethanol, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. In case of a spill, it should be immediately contained and cleaned up using appropriate cleaning agents. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.