2-[(2R)-2-Piperidinyl]ethanol(CAS: 68419-38-5)

2-[(2R)-2-Piperidinyl]ethanol is a colorless liquid with a distinctive odor. Its molecular weight is approximately 149.26 g/mol. It is soluble in water and ethanol. Chemically, it is relatively stable but can undergo hydrolysis under basic conditions. It is a chiral molecule with a stereogenic center at the 2-position of the piperidine ring.

2-[(2R)-2-Piperidinyl]ethanol is typically synthesized through a multi-step process involving the protection of the hydroxyl group of 2-piperidineethanol, followed by selective reduction of the ketone to an alcohol. This often involves using reducing agents like sodium borohydride and specific chiral catalysts to achieve high enantiomeric excess. The overall yield is around 70-80%.

2-[(2R)-2-Piperidinyl]ethanol is used in the pharmaceutical industry as a chiral intermediate for the synthesis of various drugs. It is also utilized in the polymer industry as an additive to improve the properties of polymers. Additionally, it has applications in sensor technology and semiconductor manufacturing as a reagent.

When handling 2-[(2R)-2-Piperidinyl]ethanol, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. In case of a spill, it should be immediately contained and cleaned up using appropriate cleaning agents. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.